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Background <p>Vitamin D plays a critical role in bone metabolism, calcium regulation, and various cellular processes, including those linked to cancer. The biologically active form, 1,25-dihydroxyvitamin D [1,25(OH)2D], works through the Vitamin D Receptor (VDR). Polymorphisms in VDR and related genes have been associated with cancer risk, including breast cancer. This case-control study aimed to investigate the relationship between serum vitamin D levels and breast cancer among Kenyan women.</p> Methods <p>Serum 25-hydroxyvitamin D [25(OH)D] levels were measured in 112 breast cancer patients and 106 controls using electrochemiluminescence.</p> Results <p>Results indicated that 81.2% of participants had deficient or insufficient vitamin D levels, with controls showing slightly higher sufficient levels compared to cases. Although previous studies suggested an association between higher vitamin D levels and reduced breast cancer risk, our findings revealed no significant link between vitamin D levels and various demographic factors, including BMI.</p> Conclusion <p>The study underscores the need for public awareness about vitamin D supplementation and further research to clarify the role of vitamin D in breast cancer development, particularly in populations with widespread vitamin D deficiency.</p>

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Vitamin D status and risk for breast cancer in Kenya

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月3日

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  • Ronald Wasike,
  • Victor Mobegi,
  • Esther Maina,
  • Francis Makokha,
  • Robert Armstrong,
  • Annastacia Mbithi

摘要

Background

Vitamin D plays a critical role in bone metabolism, calcium regulation, and various cellular processes, including those linked to cancer. The biologically active form, 1,25-dihydroxyvitamin D [1,25(OH)2D], works through the Vitamin D Receptor (VDR). Polymorphisms in VDR and related genes have been associated with cancer risk, including breast cancer. This case-control study aimed to investigate the relationship between serum vitamin D levels and breast cancer among Kenyan women.

Methods

Serum 25-hydroxyvitamin D [25(OH)D] levels were measured in 112 breast cancer patients and 106 controls using electrochemiluminescence.

Results

Results indicated that 81.2% of participants had deficient or insufficient vitamin D levels, with controls showing slightly higher sufficient levels compared to cases. Although previous studies suggested an association between higher vitamin D levels and reduced breast cancer risk, our findings revealed no significant link between vitamin D levels and various demographic factors, including BMI.

Conclusion

The study underscores the need for public awareness about vitamin D supplementation and further research to clarify the role of vitamin D in breast cancer development, particularly in populations with widespread vitamin D deficiency.