Amino acids to prevent cardiac surgery-associated acute kidney injury: a randomized controlled trial

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2024年3月26日

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Masahiro Kazawa,
Daijiro Kabata,
Hisako Yoshida,
Kimito Minami,
Takuma Maeda,
Kenji Yoshitani,
Hitoshi Matsuda,
Ayumi Shintani

摘要

Background

This study aimed to examine the preventive effect of amino acids on postoperative acute kidney injury (AKI).

Methods

This was single-center, patient- and assessor-blinded, randomized controlled trial. Patients who underwent aortic surgery with cardiopulmonary bypass were included. The intervention group received 60 g/day of amino acids for up to 3 days. The control group received standard care. The primary outcome was the incidence of AKI. We assessed the effect of amino acids on AKI using a Cox proportional hazards regression model.

Results

Sixty-six patients were randomly assigned to the control or intervention group. One patient in the control group withdrew consent after randomization. The incidence of AKI was 10 patients (30.3%) in the intervention group versus 18 patients (56.2%) in the control group (adjusted hazard ratio, 0.44; 95% confidence interval, 0.20–0.95; P = 0.04).

Conclusions

This trial demonstrated a significant reduction in AKI incidence with amino acid supplementation.

Trial registration

jRCT, jRCTs051210154. Registered 31 December 2021, https://jrct.niph.go.jp/re/reports/detail/69916