Scholarlink

<p>Triplicate electrocardiograms (ECGs) are routinely included in clinical trials where concern of agent-induced electrophysiological alterations arise. Three electrocardiograms (triplicate ECGs) are obtained over a time interval of less than 10&#xa0;min with the intent to increase recognition of changes, and to provide increased data for measurement and review of physiologic intervals. We undertook a prospective review of over 500 sets of triplicate ECGs to evaluate the added value of two additional tracings over a single ECG. Our review was done exclusively to evaluate the actual ECG tracings and not the reproducibility of the electronic interpretive algorithms. All ECGs were reviewed by one of the cardiologists over a four-month period. We found no meaningful changes in R-R, P-R, or Q-T intervals, nor any change in the QRS duration that was observed during the <i>≤</i> 10-minute period of data acquisition; rare supraventricular and ventricular ectopy was noted in 4 of the 505 triplicate sets. The routine inclusion of a requirement for triplicate ECGs should be revaluated to assess the added value to the patient or clinical research as well as potential burdens to the patient and financial impact.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Clinical added value of triplicate electrocardiograms: a review of 505 triplicate sets

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月18日

查看全文
  • Michael S. Ewer,
  • Hyeon-Ju Ryo Ali,
  • Nicolas L. Palaskas,
  • Jay Herson,
  • Anita Deswal

摘要

Triplicate electrocardiograms (ECGs) are routinely included in clinical trials where concern of agent-induced electrophysiological alterations arise. Three electrocardiograms (triplicate ECGs) are obtained over a time interval of less than 10 min with the intent to increase recognition of changes, and to provide increased data for measurement and review of physiologic intervals. We undertook a prospective review of over 500 sets of triplicate ECGs to evaluate the added value of two additional tracings over a single ECG. Our review was done exclusively to evaluate the actual ECG tracings and not the reproducibility of the electronic interpretive algorithms. All ECGs were reviewed by one of the cardiologists over a four-month period. We found no meaningful changes in R-R, P-R, or Q-T intervals, nor any change in the QRS duration that was observed during the ≤ 10-minute period of data acquisition; rare supraventricular and ventricular ectopy was noted in 4 of the 505 triplicate sets. The routine inclusion of a requirement for triplicate ECGs should be revaluated to assess the added value to the patient or clinical research as well as potential burdens to the patient and financial impact.