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Purpose <p>We aimed to investigate the association between post-treatment changes in polarimetric entropy (PE), which is a noninvasive surrogate marker of structural heterogeneity associated with pigment epithelial remodeling and measured by polarization-sensitive optical coherence tomography (PS-OCT), and the need for multiple anti-vascular endothelial growth factor (VEGF)-injections in myopic choroidal neovascularization (mCNV).</p> Methods <p>We retrospectively analyzed 11 eyes that received intra-vitreal anti-VEGF injections for treatment-naïve mCNV. Based on treatment response during the first 3 months, eyes were categorized into the single-injection (<i>n</i> = 9) and multiple-injection (<i>n</i> = 2) groups. PS-OCT en face PE maps (6 × 6&#xa0;mm) were obtained at baseline and 3 months after treatment, with the analysis area manually centered over the CNV using a 3-mm Early Treatment Diabetic Retinopathy Study (ETDRS) grid. PE values were extracted from the central 1-mm circle (CNV core) and surrounding 1–3-mm annulus (periphery), and the differences before and after treatment were calculated. Intergroup comparisons were conducted using Wilcoxon rank-sum test.</p> Results <p>PE within the CNV core increased after treatment (<i>p</i> = 0.0037). The multiple-injection group showed a greater PE increase than the single-injection group (<i>p</i> = 0.0347), although this finding should be interpreted cautiously given the small and imbalanced sample size. Exploratory analysis suggested a positive association between the magnitude of PE change in the CNV core and injection number during the 3-month period.</p> Conclusions <p>High post-treatment entropy may reflect structural heterogeneity associated with pigment epithelial remodeling during the early healing phase. These findings suggest that PS-OCT entropy imaging may serve as a retrospective indicator of tissue response rather than a predictive biomarker in the present dataset. Given the very small and imbalanced sample size, the results should be interpreted as exploratory and hypothesis-generating.</p>

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Quantitative evaluation of pigment epithelial encapsulation using polarization-sensitive optical coherence tomography after anti-VEGF therapy for myopic choroidal neovascularization

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月14日

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  • Mami Ota,
  • Yuki Saeki,
  • Kazuki Yashiro,
  • Shuichiro Aoki,
  • Kohdai Kitamoto,
  • Ryo Terao,
  • Keiko Azuma

摘要

Purpose

We aimed to investigate the association between post-treatment changes in polarimetric entropy (PE), which is a noninvasive surrogate marker of structural heterogeneity associated with pigment epithelial remodeling and measured by polarization-sensitive optical coherence tomography (PS-OCT), and the need for multiple anti-vascular endothelial growth factor (VEGF)-injections in myopic choroidal neovascularization (mCNV).

Methods

We retrospectively analyzed 11 eyes that received intra-vitreal anti-VEGF injections for treatment-naïve mCNV. Based on treatment response during the first 3 months, eyes were categorized into the single-injection (n = 9) and multiple-injection (n = 2) groups. PS-OCT en face PE maps (6 × 6 mm) were obtained at baseline and 3 months after treatment, with the analysis area manually centered over the CNV using a 3-mm Early Treatment Diabetic Retinopathy Study (ETDRS) grid. PE values were extracted from the central 1-mm circle (CNV core) and surrounding 1–3-mm annulus (periphery), and the differences before and after treatment were calculated. Intergroup comparisons were conducted using Wilcoxon rank-sum test.

Results

PE within the CNV core increased after treatment (p = 0.0037). The multiple-injection group showed a greater PE increase than the single-injection group (p = 0.0347), although this finding should be interpreted cautiously given the small and imbalanced sample size. Exploratory analysis suggested a positive association between the magnitude of PE change in the CNV core and injection number during the 3-month period.

Conclusions

High post-treatment entropy may reflect structural heterogeneity associated with pigment epithelial remodeling during the early healing phase. These findings suggest that PS-OCT entropy imaging may serve as a retrospective indicator of tissue response rather than a predictive biomarker in the present dataset. Given the very small and imbalanced sample size, the results should be interpreted as exploratory and hypothesis-generating.