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<p>While blue vital dyes remain indispensable in ophthalmic surgery, medication errors, particularly the inadvertent use of methylene blue instead of trypan blue and brilliant blue, pose a significant risk to patient safety. Methylene blue has been reported to cause damage to anterior segment structures, We reported a case of inner retinal toxicity from injection of methylene blue into the vitreous cavity resulting in profound vision loss. Standardization, vigilant verification, and safer packaging are critical to preventing these never events.</p>

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A case of the blue blues: the safety issue of recognizing and avoiding the retinal toxicity of methylene blue compared to brilliant blue and trypan blue

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月5日

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  • Sidra Zafar,
  • Jose S. Pulido,
  • Samir N. Patel,
  • Yoshihiro Yonekawa,
  • Jordan D. Deaner

摘要

While blue vital dyes remain indispensable in ophthalmic surgery, medication errors, particularly the inadvertent use of methylene blue instead of trypan blue and brilliant blue, pose a significant risk to patient safety. Methylene blue has been reported to cause damage to anterior segment structures, We reported a case of inner retinal toxicity from injection of methylene blue into the vitreous cavity resulting in profound vision loss. Standardization, vigilant verification, and safer packaging are critical to preventing these never events.