Background <p>We evaluated the clinical outcomes of selective retina therapy (SRT) in patients with central serous chorioretinopathy (CSC) who had nonconforming focal choroidal excavations (FCEs).</p> Methods <p>Among the 204 patients with chronic CSC who underwent SRT between June 2023 and February 2025, six patients (2.9%) with nonconforming FCEs were analyzed. Using a Q-switched Nd: YLF 527-nm laser device, SRT was applied at leaking points or in leakage areas according to the features observed on fundus fluorescein angiography. The mean best-corrected visual acuity (BCVA), central foveal thickness (CFT), subfoveal choroidal thickness height, and mean deviation (MD) of retinal sensitivity were measured during the follow-up period.</p> Results <p>Among the six patients, five patients showed complete subretinal fluid (SRF) resolution, while one patient demonstrated minimal persistent SRF during the follow-up period. Four patients showed an improvement in BCVA, while BCVA remained unchanged in the other two patients. All patients showed improvement in the MD of retinal sensitivity during the follow-up period. Among the six patients, two patients showed complete SRF resolution after a single session of SRT, while the other four patients required multiple SRT sessions. No SRT-related adverse events were observed during the follow-up period.</p> Conclusion <p>SRT produced favorable outcomes in the treatment of patients with CSC and nonconforming FCEs. </p>