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<p>The mitigative potential of <i>Ocimum gratissimum</i> aqueous leaf extract (OG) in metabolic diseases is well documented. The impact of exercise on its cardiometabolic effect in obese male Wistar rats is however not known, hence the current study. Twenty-five, 4 weeks old, male Wistar rats were grouped into five as I-V. Group I comprised normal rats fed a standard diet while obesity was induced in II-V using high-fat diet (HFD) for 12 weeks. While on their respective diets, I and II received distilled water, III underwent exercise 30&#xa0;min, five times per week, IV received 400&#xa0;mg/kg of OG; and V were exercised and administered OG for another 10 weeks. Lee Index was calculated; Systolic (SBP), Diastolic (DBP), and Mean Arterial Blood Pressure (MABP) were non-invasively measured. Oral glucose tolerance test (OGTT) was carried out. Fasting blood glucose (FBG), insulin, lipid profile and oxidative stress biomarkers were determined in the blood and hepatic glycogen content was assayed. Lee index (318.9 ± 3.60 vs. 283.21 ± 7.15), area under the curve of OGTT (13721 ± 106.70 vs. 10727 ± 463.50&#xa0;mg.min/dL), SBP (161.1 ± 2.65 vs. 104.7 ± 1.45mmHg), DBP (110.4 ± 5.84 vs. 79.5 ± 2.79mmHg), MABP (126.8 ± 4.58 vs. 87.6 ± 1.52mmHg), FBG (113.3 ± 3.18 vs. 87.0 ± 3.79&#xa0;mg/dL), and malondialdehyde level (95.96 ± 1.04 vs. 73.74 ± 2.02 × 10<sup>− 2</sup> µM/mL) were increased in II relative to I. These variables were reversed in III-V with respect to II. Insulin increased in the exercised groups (III and V) while hepatic glycogen was reduced in III when compared with II. Exercise and/or OG improved selected cardiometabolic alterations in obese male Wistar rats. Evidence for a synergistic effect requires further statistical confirmation.</p>

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Combining swim exercise and Ocimum gratissimum leaf extract: a dual approach to mitigate cardiometabolic derangement in obese male Wistar rats

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月4日

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  • S. T. Shittu,
  • B. I. Dare,
  • J. O. Omolanwo,
  • S. A. Shittu,
  • G. O. Isehunwa,
  • T. J. Lasisi,
  • A. R. A. Alada

摘要

The mitigative potential of Ocimum gratissimum aqueous leaf extract (OG) in metabolic diseases is well documented. The impact of exercise on its cardiometabolic effect in obese male Wistar rats is however not known, hence the current study. Twenty-five, 4 weeks old, male Wistar rats were grouped into five as I-V. Group I comprised normal rats fed a standard diet while obesity was induced in II-V using high-fat diet (HFD) for 12 weeks. While on their respective diets, I and II received distilled water, III underwent exercise 30 min, five times per week, IV received 400 mg/kg of OG; and V were exercised and administered OG for another 10 weeks. Lee Index was calculated; Systolic (SBP), Diastolic (DBP), and Mean Arterial Blood Pressure (MABP) were non-invasively measured. Oral glucose tolerance test (OGTT) was carried out. Fasting blood glucose (FBG), insulin, lipid profile and oxidative stress biomarkers were determined in the blood and hepatic glycogen content was assayed. Lee index (318.9 ± 3.60 vs. 283.21 ± 7.15), area under the curve of OGTT (13721 ± 106.70 vs. 10727 ± 463.50 mg.min/dL), SBP (161.1 ± 2.65 vs. 104.7 ± 1.45mmHg), DBP (110.4 ± 5.84 vs. 79.5 ± 2.79mmHg), MABP (126.8 ± 4.58 vs. 87.6 ± 1.52mmHg), FBG (113.3 ± 3.18 vs. 87.0 ± 3.79 mg/dL), and malondialdehyde level (95.96 ± 1.04 vs. 73.74 ± 2.02 × 10− 2 µM/mL) were increased in II relative to I. These variables were reversed in III-V with respect to II. Insulin increased in the exercised groups (III and V) while hepatic glycogen was reduced in III when compared with II. Exercise and/or OG improved selected cardiometabolic alterations in obese male Wistar rats. Evidence for a synergistic effect requires further statistical confirmation.