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Background <p>Processed meat is classified as a Group 1 carcinogen; however, evidence from Latin America—particularly Brazil—regarding its role in gastric adenocarcinoma (GA) remains limited. We examined the association between processed meat intake of GA among adults in Brazil’s Central-West region.</p> Methods <p>This case–control study included 553 participants (166 cases, 189 endoscopic controls, and 198 hospital controls). Processed meat intake was assessed using a validated food frequency questionnaire. Associations were estimated using logistic regression models, calculating odds ratios (OR) and 95% confidence intervals (95% CI) for each 10&#xa0;g/day increment in processed meat consumption. Adjusted predicted probabilities were estimated using post-estimation marginal effects to evaluate dose–response patterns across an intake range of 0–40&#xa0;g/day.</p> Results <p>Higher processed meat intake was associated with an increased risk of GA in both comparisons, with an OR of 1.53 (95% CI: 1.09–2.15) using endoscopic controls and an OR of 1.28 (95% CI: 1.02–1.61) using hospital controls. Predictive margins showed an approximately linear dose–response pattern.</p> Conclusion <p>These findings provide evidence from an understudied Brazilian region and suggest processed meat intake as a potentially modifiable risk factor for GA.</p>

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Processed meat intake and gastric adenocarcinoma risk among adults in Central-West Brazil: a case–control study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月14日

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  • Silvana Barbosa Santiago,
  • Alex Richard Costa Silva,
  • Maria Paula Curado,
  • Amanda Ferreira Paes Landim Ramos,
  • Ana Luísa Santos Bizinoto,
  • Alexandre Menezes de Brito,
  • Daniela Medeiros Milhomem Cardoso,
  • Leonardo Medeiros Milhomem,
  • Gisele Aparecida Fernandes,
  • Mônica Santiago Barbosa

摘要

Background

Processed meat is classified as a Group 1 carcinogen; however, evidence from Latin America—particularly Brazil—regarding its role in gastric adenocarcinoma (GA) remains limited. We examined the association between processed meat intake of GA among adults in Brazil’s Central-West region.

Methods

This case–control study included 553 participants (166 cases, 189 endoscopic controls, and 198 hospital controls). Processed meat intake was assessed using a validated food frequency questionnaire. Associations were estimated using logistic regression models, calculating odds ratios (OR) and 95% confidence intervals (95% CI) for each 10 g/day increment in processed meat consumption. Adjusted predicted probabilities were estimated using post-estimation marginal effects to evaluate dose–response patterns across an intake range of 0–40 g/day.

Results

Higher processed meat intake was associated with an increased risk of GA in both comparisons, with an OR of 1.53 (95% CI: 1.09–2.15) using endoscopic controls and an OR of 1.28 (95% CI: 1.02–1.61) using hospital controls. Predictive margins showed an approximately linear dose–response pattern.

Conclusion

These findings provide evidence from an understudied Brazilian region and suggest processed meat intake as a potentially modifiable risk factor for GA.