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Background <p>Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder in reproductive-age women. Dietary patterns may influence its development through inflammatory and metabolic pathways.</p> Objective <p>To evaluate the association between adherence to the Diabetes Risk Reduction Diet (DRRD) and the risk and severity of PCOS.</p> Methods <p>This case-control study included 232 women with newly diagnosed PCOS and 206 healthy controls aged 19–45 years. Dietary intake was assessed using a validated food frequency questionnaire (FFQ), and DRRD scores were calculated based on nine components. Anthropometric, biochemical, and psychological parameters were measured. Multivariate logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for PCOS across DRRD tertiles.</p> Results <p>Participants in the highest DRRD tertile had significantly lower odds of PCOS PCOS (OR: 0.14, 95% CI: 0.08–0.25, <i>p</i> &lt; 0.001; <i>p</i>-trend &lt; 0.001) compared to the lowest tertile, even after adjusting for confounders. Higher DRRD adherence was associated with better metabolic and psychological profiles, though findings on specific biochemical parameters were mixed.</p> Conclusion <p>Higher adherence to the DRRD is associated with a reduced likelihood of PCOS. These findings support the role of anti-inflammatory dietary patterns in PCOS prevention.</p>

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Association between the diabetes risk reduction diet and polycystic ovary syndrome

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月2日

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  • Maryam Jamalvandi,
  • Hawal Lateef Fateh,
  • Touraj Ahmadi,
  • Jalal Moludi,
  • Mehnoosh Samadi,
  • Mehdi Moradinazar

摘要

Background

Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder in reproductive-age women. Dietary patterns may influence its development through inflammatory and metabolic pathways.

Objective

To evaluate the association between adherence to the Diabetes Risk Reduction Diet (DRRD) and the risk and severity of PCOS.

Methods

This case-control study included 232 women with newly diagnosed PCOS and 206 healthy controls aged 19–45 years. Dietary intake was assessed using a validated food frequency questionnaire (FFQ), and DRRD scores were calculated based on nine components. Anthropometric, biochemical, and psychological parameters were measured. Multivariate logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for PCOS across DRRD tertiles.

Results

Participants in the highest DRRD tertile had significantly lower odds of PCOS PCOS (OR: 0.14, 95% CI: 0.08–0.25, p < 0.001; p-trend < 0.001) compared to the lowest tertile, even after adjusting for confounders. Higher DRRD adherence was associated with better metabolic and psychological profiles, though findings on specific biochemical parameters were mixed.

Conclusion

Higher adherence to the DRRD is associated with a reduced likelihood of PCOS. These findings support the role of anti-inflammatory dietary patterns in PCOS prevention.