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Background <p>Although the main cause of polycystic ovarian syndrome (PCOS) is still unknown, diet plays a significant role in the pathophysiology of PCOS, possibly through effects on the inflammatory response and oxidative stress pathways in the body.</p> Method <p>The present study was conducted as a case‒control study on 45 women with PCOS and 40 healthy women in the control group between May 2021 and February 2022 in Robat Karim, Iran. A food frequency questionnaire (FFQ) was completed for all participants, and the antioxidant indices of the diet were calculated via two different methods: ferric reducing ability of plasma (FRAP) and oxygen radical absorption capacity (ORAC) using the data obtained from the FFQ.</p> Results <p>The antioxidant indices of the diet determined via the FRAP index were significantly lower in the women with PCOS than in the control group (4.94 ± 1.97 vs. 3.48 ± 1.77, P˂ 0.05), but no significant difference was observed between the two groups in terms of the antioxidant index of the diet based on the ORAC index (P˃ 0.05). Additionally, the antioxidant indices of the diet based on both the ORAC (<i>R</i> = 0.94, P˃ 0.05) and FRAP (<i>R</i> = 0.82, P˃ 0.05) indices were not significantly correlated with the inflammatory marker interleukin-6 (IL-6).</p> Conclusion <p>The present study supports the hypothesis of the importance of diet, especially food antioxidants, in the occurrence and exacerbation of PCOS, but the use of a suitable tool to determine the general antioxidant index of the diet in epidemiological studies related to diet and PCOS seems necessary.</p>

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Association of the dietary anti-oxidant index with inflammatory marker such as interleukin-6 in women with and without polycystic ovarian syndrome: a comparative case‒control study

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  • 发表日期：

    2025年11月25日

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  • Khadijeh Azarbayjani,
  • Shahideh Jahanian Sadatmahalleh,
  • Azadeh Mottaghi,
  • Malihe Nasiri

摘要

Background

Although the main cause of polycystic ovarian syndrome (PCOS) is still unknown, diet plays a significant role in the pathophysiology of PCOS, possibly through effects on the inflammatory response and oxidative stress pathways in the body.

Method

The present study was conducted as a case‒control study on 45 women with PCOS and 40 healthy women in the control group between May 2021 and February 2022 in Robat Karim, Iran. A food frequency questionnaire (FFQ) was completed for all participants, and the antioxidant indices of the diet were calculated via two different methods: ferric reducing ability of plasma (FRAP) and oxygen radical absorption capacity (ORAC) using the data obtained from the FFQ.

Results

The antioxidant indices of the diet determined via the FRAP index were significantly lower in the women with PCOS than in the control group (4.94 ± 1.97 vs. 3.48 ± 1.77, P˂ 0.05), but no significant difference was observed between the two groups in terms of the antioxidant index of the diet based on the ORAC index (P˃ 0.05). Additionally, the antioxidant indices of the diet based on both the ORAC (R = 0.94, P˃ 0.05) and FRAP (R = 0.82, P˃ 0.05) indices were not significantly correlated with the inflammatory marker interleukin-6 (IL-6).

Conclusion

The present study supports the hypothesis of the importance of diet, especially food antioxidants, in the occurrence and exacerbation of PCOS, but the use of a suitable tool to determine the general antioxidant index of the diet in epidemiological studies related to diet and PCOS seems necessary.