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Aims/Hypothesis <p>This secondary analysis compared the effect of a vegan to a portion-controlled diet on insulin use and insulin costs in people with type 1 diabetes (T1D).</p> Methods <p>Fifty-eight adults with T1D were randomly assigned to a vegan (<i>n</i> = 29) or a portion-controlled group (<i>n</i> = 29) for 12 weeks. Federal Supply Schedule pharmaceutical pricing was used to assess insulin costs.</p> Results <p>Total dose of insulin decreased by 12.1 units/day in the vegan group (<i>p</i> = 0.007), compared to no significant change in the portion-controlled group (treatment effect − 10.7 units/day [95% CI, -21.3 to -0.2]; <i>p</i> = 0.046). Total insulin costs decreased by 27% ($1.08/day; <i>p</i> = 0.003) in the vegan group, compared to no significant change in the portion-controlled group (-$0.38/day [95% CI, -$2.13 to +$1.38]; <i>p</i> = 0.66).</p> Conclusions/Interpretation <p>This study shows that a low-fat vegan diet could reduce insulin use and insulin costs in people with T1D. Larger trials are needed to confirm these findings.</p> Trial registration <p><a href="http://ClinicalTrials.gov">ClinicalTrials.gov</a>, NCT04944316, registered on June 29, 2021.</p>

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Can a vegan diet help people with type 1 diabetes save on insulin? A secondary analysis of a 12-Week randomized clinical trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月14日

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  • Hana Kahleova,
  • Cristina Maracine,
  • Tatiana Znayenko-Miller,
  • Shihchen Kuo,
  • William H. Herman,
  • Richard Holubkov,
  • Neal D. Barnard

摘要

Aims/Hypothesis

This secondary analysis compared the effect of a vegan to a portion-controlled diet on insulin use and insulin costs in people with type 1 diabetes (T1D).

Methods

Fifty-eight adults with T1D were randomly assigned to a vegan (n = 29) or a portion-controlled group (n = 29) for 12 weeks. Federal Supply Schedule pharmaceutical pricing was used to assess insulin costs.

Results

Total dose of insulin decreased by 12.1 units/day in the vegan group (p = 0.007), compared to no significant change in the portion-controlled group (treatment effect − 10.7 units/day [95% CI, -21.3 to -0.2]; p = 0.046). Total insulin costs decreased by 27% ($1.08/day; p = 0.003) in the vegan group, compared to no significant change in the portion-controlled group (-$0.38/day [95% CI, -$2.13 to +$1.38]; p = 0.66).

Conclusions/Interpretation

This study shows that a low-fat vegan diet could reduce insulin use and insulin costs in people with T1D. Larger trials are needed to confirm these findings.

Trial registration

ClinicalTrials.gov, NCT04944316, registered on June 29, 2021.