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Background <p>Cancer pharmacotherapy has shifted to outpatient settings, making community pharmacists essential for ensuring medication safety. Although community pharmacist prescription audits are important, evidence regarding the clinical significance of their prescription audits for oral anticancer agents remains limited. This study aimed to analyze the content of inquiries regarding oral anticancer drugs and clarify the details of prescription audits conducted by community pharmacists.</p> Methods <p>This single-institution retrospective a descriptive observational study included all records of inquiries regarding oral anticancer drugs submitted from community pharmacies to the National Cancer Center Hospital East between September 2023 and March 2025. Inquiry content was categorized based on treatment efficacy and safety concerns, while the level of pharmacist intervention was assessed based on the severity of the medication error and the clinical value of the pharmacist service. As the purpose of this study is to investigate prescription audits by community pharmacies, interventions unrelated to prescription auditing, such as telephone follow-ups or tracing reports, were excluded.</p> Results <p>During the study period, 184,688 prescriptions were issued, of which 384 inquiries (0.2%) involved oral anticancer agents and were included in the analysis. Prescription modifications occurred in 295 cases (77%). The most common inquiry categories were incorrect treatment duration (23%), adjustment for leftover medication (20%), and dosage errors (16%). Overall, 49% of cases were classified as potentially lethal, serious, or significant medication-order errors, and 49% were assessed as having a value of service of significant or higher. High-severity and high-value interventions most frequently involved errors in treatment duration and dosage.</p> Conclusions <p>Prescription inquiries regarding oral anticancer agents frequently identified clinically significant prescribing issues, and community pharmacists provided high-value interventions. These findings indicate that community pharmacists play a crucial role in conducting high-quality prescription audits and enhancing the safety of outpatient cancer drug therapy.</p>

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Details of oral anticancer drug prescription audits by community pharmacists: a retrospective analysis of prescription inquiries

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月7日

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  • Yuma Shibutani,
  • Keito Ikou,
  • Shinya Suzuki,
  • Sayaka Nakajima,
  • Akiko Hashimoto,
  • Azumi Sako,
  • Naoko Kumazawa,
  • Yasuaki Ryusima,
  • Masahito Yonemura,
  • Naoki Kondo

摘要

Background

Cancer pharmacotherapy has shifted to outpatient settings, making community pharmacists essential for ensuring medication safety. Although community pharmacist prescription audits are important, evidence regarding the clinical significance of their prescription audits for oral anticancer agents remains limited. This study aimed to analyze the content of inquiries regarding oral anticancer drugs and clarify the details of prescription audits conducted by community pharmacists.

Methods

This single-institution retrospective a descriptive observational study included all records of inquiries regarding oral anticancer drugs submitted from community pharmacies to the National Cancer Center Hospital East between September 2023 and March 2025. Inquiry content was categorized based on treatment efficacy and safety concerns, while the level of pharmacist intervention was assessed based on the severity of the medication error and the clinical value of the pharmacist service. As the purpose of this study is to investigate prescription audits by community pharmacies, interventions unrelated to prescription auditing, such as telephone follow-ups or tracing reports, were excluded.

Results

During the study period, 184,688 prescriptions were issued, of which 384 inquiries (0.2%) involved oral anticancer agents and were included in the analysis. Prescription modifications occurred in 295 cases (77%). The most common inquiry categories were incorrect treatment duration (23%), adjustment for leftover medication (20%), and dosage errors (16%). Overall, 49% of cases were classified as potentially lethal, serious, or significant medication-order errors, and 49% were assessed as having a value of service of significant or higher. High-severity and high-value interventions most frequently involved errors in treatment duration and dosage.

Conclusions

Prescription inquiries regarding oral anticancer agents frequently identified clinically significant prescribing issues, and community pharmacists provided high-value interventions. These findings indicate that community pharmacists play a crucial role in conducting high-quality prescription audits and enhancing the safety of outpatient cancer drug therapy.