Background The aim was to determine the effects of 8 weeks of concurrent training of abbreviated high-intensity interval-training and low–load resistance training (CTHIIT+RT) on functional and structural vascular outcomes of breast cancer survivors with a history of high or low exposure to chemotherapy sessions. Methods Breast cancer survivor women (n = 21, 58.7 ± 8.7 years) were divided into high– (HVchemo, n = 11) or low–volume chemotherapy groups (LVchemo, n = 10). Pulse wave velocity (PWV) and carotid intima–media maximum (cIMTmax) were the primary outcomes, while flow-mediated dilation (FMD), carotid intima–media average (cIMTav), baseline brachial artery diameter (Dbase), peak diameter (Dpeak), and one-repetition maximum tests for the biceps (1RMbc), shoulder (1RMsp), back (1RMback), and leg extension (1RMLeg) served as secondary outcomes. Results PWV decreased in the LVchemo group (∆˗1.64 m⋅s− 1, p < 0.001) but not in the HVchemo group. cIMTmax was reduced only in the HVchemo group (∆˗0.23 mm, p = 0.024). FMD was significantly increased in the HVchemo (∆+5.06%, p = 0.023) but not in the LVchemo group. HVchemo and LVchemo groups increased Dbase (∆+0.38 mm, p = 0.005; and ∆+0.16 mm, p < 0.0001) and Dpeak (∆+0.32 mm, p = 0.008; and ∆+0.12 mm, p < 0.0001). HVchemo and LVchemo groups increase 1RMbc (∆+2.3 kg; and ∆+2.09 kg), 1RMsp (∆+2.15 kg; and ∆+2.36 kg), 1RMback (∆+4.4 kg; and ∆+4.58 kg), and 1RMLeg (∆+6.15 kg; and ∆+5.27 kg), all p < 0.01. Conclusions Eight weeks of CTHIIT+RT in women breast cancer survivors who received higher chemotherapy volume reduces cIMTmax, but increases FMD, Dbase, Dpeak, cardiorespiratory fitness, and muscle strength. Vascular improvements were partially observed in subjects with lower chemotherapy volumes.

Concurrent high-intensity interval plus resistance training improves vascular health in breast cancer survivors with high chemotherapy exposure

期刊论文
出版模式：

开放获取
发表日期：

2026年2月23日

查看全文

Cristian Álvarez,
Carolina Fuentes,
Cristóbal Durán-Marín,
Pedro Delgado-Floody,
Gabriel Rojas-Rojas,
Manuel Gomez,
Alvaro N. Gurovich,
David C. Andrade

摘要

Background

The aim was to determine the effects of 8 weeks of concurrent training of abbreviated high-intensity interval-training and low–load resistance training (CT_HIIT+RT) on functional and structural vascular outcomes of breast cancer survivors with a history of high or low exposure to chemotherapy sessions.

Methods

Breast cancer survivor women (n = 21, 58.7 ± 8.7 years) were divided into high– (HV_chemo, n = 11) or low–volume chemotherapy groups (LV_chemo, n = 10). Pulse wave velocity (PWV) and carotid intima–media maximum (cIMT_max) were the primary outcomes, while flow-mediated dilation (FMD), carotid intima–media average (cIMT_av), baseline brachial artery diameter (D_base), peak diameter (D_peak), and one-repetition maximum tests for the biceps (1RM_bc), shoulder (1RM_sp), back (1RM_back), and leg extension (1RM_Leg) served as secondary outcomes.

Results

PWV decreased in the LV_chemo group (∆˗1.64 m⋅s^− 1, p < 0.001) but not in the HV_chemo group. cIMT_max was reduced only in the HV_chemo group (∆˗0.23 mm, p = 0.024). FMD was significantly increased in the HV_chemo (∆+5.06%, p = 0.023) but not in the LV_chemo group. HV_chemo and LV_chemo groups increased D_base (∆+0.38 mm, p = 0.005; and ∆+0.16 mm, p < 0.0001) and D_peak (∆+0.32 mm, p = 0.008; and ∆+0.12 mm, p < 0.0001). HV_chemo and LV_chemo groups increase 1RM_bc (∆+2.3 kg; and ∆+2.09 kg), 1RM_sp (∆+2.15 kg; and ∆+2.36 kg), 1RM_back (∆+4.4 kg; and ∆+4.58 kg), and 1RM_Leg (∆+6.15 kg; and ∆+5.27 kg), all p < 0.01.

Conclusions

Eight weeks of CT_HIIT+RT in women breast cancer survivors who received higher chemotherapy volume reduces cIMT_max, but increases FMD, D_base, D_peak, cardiorespiratory fitness, and muscle strength. Vascular improvements were partially observed in subjects with lower chemotherapy volumes.