Scholarlink

Background <p>The image quality of positron emission tomography (PET) can be significantly enhanced by using time-of-flight (TOF) and depth-of-interaction (DOI) information. PET detectors are pivotal in determining the TOF and DOI capabilities of PET scanners.</p> Methods <p>This study developed and evaluated TOF-DOI PET detectors based on the dual-ended readout method and lutetium-yttrium oxyorthosilicate (LYSO) arrays with two different pitches and reflector configurations. Specifically, the performance of detectors based on three types of LYSO arrays with 20 mm thickness, 8 × 8 arrays with a 3.2&#xa0;mm pitch, 16 × 16 arrays with a 1.6&#xa0;mm pitch and normal reflectors, and 16 × 16 arrays with a 1.6&#xa0;mm pitch and partial short reflectors, were assessed. Hamamatsu S14161-3050-08 silicon photomultiplier arrays were used as the photodetectors, and PETsys TOFPET2 was used as the readout electronics.</p> Results <p>The flood histograms showed that all crystals in the three types of LYSO arrays were clearly resolved. The detectors based on the 8 × 8 LYSO arrays provided a coincidence timing resolution (CTR) of 207 ± 5&#xa0;ps and a DOI resolution of 3.9 ± 0.6&#xa0;mm. The detectors based on the 16 × 16 LYSO arrays with normal reflectors provided a CTR of 218 ± 7&#xa0;ps and a DOI resolution of 2.6 ± 0.2&#xa0;mm. In comparison, the detector based on the 16 × 16 LYSO arrays with partial short reflectors provided a CTR of 228 ± 11&#xa0;ps and a DOI resolution of 2.9 ± 0.3&#xa0;mm, and superior crystal resolvability compared to the detectors based on the 16 × 16 LYSO arrays with normal reflectors.</p> Conclusion <p>These detectors are promising candidates for developing whole-body and brain PET scanners, offering effective sensitivity and uniform spatial resolution improvements across the field-of-view.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Dual-ended readout TOF-DOI PET detectors based on 3.2 mm and 1.6 mm pitch LYSO arrays

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月27日

查看全文
  • Haibo Wang,
  • Jiahao Xie,
  • Jinyi Qi,
  • Simon R. Cherry,
  • Junwei Du

摘要

Background

The image quality of positron emission tomography (PET) can be significantly enhanced by using time-of-flight (TOF) and depth-of-interaction (DOI) information. PET detectors are pivotal in determining the TOF and DOI capabilities of PET scanners.

Methods

This study developed and evaluated TOF-DOI PET detectors based on the dual-ended readout method and lutetium-yttrium oxyorthosilicate (LYSO) arrays with two different pitches and reflector configurations. Specifically, the performance of detectors based on three types of LYSO arrays with 20 mm thickness, 8 × 8 arrays with a 3.2 mm pitch, 16 × 16 arrays with a 1.6 mm pitch and normal reflectors, and 16 × 16 arrays with a 1.6 mm pitch and partial short reflectors, were assessed. Hamamatsu S14161-3050-08 silicon photomultiplier arrays were used as the photodetectors, and PETsys TOFPET2 was used as the readout electronics.

Results

The flood histograms showed that all crystals in the three types of LYSO arrays were clearly resolved. The detectors based on the 8 × 8 LYSO arrays provided a coincidence timing resolution (CTR) of 207 ± 5 ps and a DOI resolution of 3.9 ± 0.6 mm. The detectors based on the 16 × 16 LYSO arrays with normal reflectors provided a CTR of 218 ± 7 ps and a DOI resolution of 2.6 ± 0.2 mm. In comparison, the detector based on the 16 × 16 LYSO arrays with partial short reflectors provided a CTR of 228 ± 11 ps and a DOI resolution of 2.9 ± 0.3 mm, and superior crystal resolvability compared to the detectors based on the 16 × 16 LYSO arrays with normal reflectors.

Conclusion

These detectors are promising candidates for developing whole-body and brain PET scanners, offering effective sensitivity and uniform spatial resolution improvements across the field-of-view.