Scholarlink

Objective <p>To evaluate the diagnostic value of combining real-time shear wave elastography (SWE) with serum thyroglobulin (Tg) in thyroid cancer (TC) and explore its potential for assessing tumor aggressiveness.</p> Methods <p>This retrospective study included 124 patients with TC and 62 with benign thyroid lesions (January 2024–August 2025). Malignant cases were classified as invasive (<i>n</i> = 78) or non-invasive (<i>n</i> = 46) based on capsular involvement, vascular invasion, or lymph node metastasis. All patients underwent SWE and Tg testing. SWE parameters—maximum (Emax), mean (Emean), minimum (Emin) Young’s modulus—and Tg levels were compared. ROC analysis assessed diagnostic performance, while Spearman correlation examined relationships between SWE and Tg.</p> Results <p>All malignant cases were papillary thyroid carcinoma. Malignant cases had higher SWE parameters and Tg than benign cases (<i>P</i> &lt; 0.05). Invasive tumors showed higher Emax, Emean, and Tg than non-invasive tumors (<i>P</i> &lt; 0.05). The combined SWE–Tg model AUC for malignancy was 0.844; for aggressiveness, 0.744. Tg correlated positively with SWE parameters (<i>P</i> &lt; 0.001).</p> Conclusion <p>Combining SWE with Tg improved discrimination between TC and benign thyroid nodules in this cohort and may provide auxiliary value for preoperative assessment of invasive features.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Predictive value of real-time shear wave elastography combined with serum thyroglobulin in thyroid cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月3日

查看全文
  • Yunyan Fang,
  • Biaohu Liu,
  • Huijun Feng,
  • Jing Hu

摘要

Objective

To evaluate the diagnostic value of combining real-time shear wave elastography (SWE) with serum thyroglobulin (Tg) in thyroid cancer (TC) and explore its potential for assessing tumor aggressiveness.

Methods

This retrospective study included 124 patients with TC and 62 with benign thyroid lesions (January 2024–August 2025). Malignant cases were classified as invasive (n = 78) or non-invasive (n = 46) based on capsular involvement, vascular invasion, or lymph node metastasis. All patients underwent SWE and Tg testing. SWE parameters—maximum (Emax), mean (Emean), minimum (Emin) Young’s modulus—and Tg levels were compared. ROC analysis assessed diagnostic performance, while Spearman correlation examined relationships between SWE and Tg.

Results

All malignant cases were papillary thyroid carcinoma. Malignant cases had higher SWE parameters and Tg than benign cases (P < 0.05). Invasive tumors showed higher Emax, Emean, and Tg than non-invasive tumors (P < 0.05). The combined SWE–Tg model AUC for malignancy was 0.844; for aggressiveness, 0.744. Tg correlated positively with SWE parameters (P < 0.001).

Conclusion

Combining SWE with Tg improved discrimination between TC and benign thyroid nodules in this cohort and may provide auxiliary value for preoperative assessment of invasive features.