Scholarlink

<p>Despite improved cancer mortality rates, pediatric cancer survivors face significant challenges in the long term due to therapy-related complications. A critical complication is the development of second malignant neoplasms (SMNs), which account for nearly half of non-relapse deaths among long-term survivors. This imaging review touches upon various risk factors for SMN development such as chemotherapeutic drugs, radiation, hereditary syndromes, and hematopoietic stem cell transplantation. Common SMNs include leukemia, thyroid cancer, sarcoma, and breast carcinoma. Early detection through imaging and structured surveillance is critical for improving outcomes. Strategies to mitigate risks include dose modification, advanced radiation techniques, and comprehensive survivorship care. As the field of pediatric oncology progresses, a dual focus on optimizing primary cancer treatment and minimizing late effects like SMNs is paramount. Lifelong surveillance, tailored therapies, and interdisciplinary care models are essential for enhancing survivors’ quality of life.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Surviving childhood cancer: the hidden threat of second malignancies

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月27日

查看全文
  • Ritu Shah,
  • Sireesha Yedururi,
  • Rhea A. Morani,
  • Ishan Arora,
  • Mary Austin,
  • Nisha S. Ramani,
  • Cynthia E. Herzog,
  • Priya R. Bhosale

摘要

Despite improved cancer mortality rates, pediatric cancer survivors face significant challenges in the long term due to therapy-related complications. A critical complication is the development of second malignant neoplasms (SMNs), which account for nearly half of non-relapse deaths among long-term survivors. This imaging review touches upon various risk factors for SMN development such as chemotherapeutic drugs, radiation, hereditary syndromes, and hematopoietic stem cell transplantation. Common SMNs include leukemia, thyroid cancer, sarcoma, and breast carcinoma. Early detection through imaging and structured surveillance is critical for improving outcomes. Strategies to mitigate risks include dose modification, advanced radiation techniques, and comprehensive survivorship care. As the field of pediatric oncology progresses, a dual focus on optimizing primary cancer treatment and minimizing late effects like SMNs is paramount. Lifelong surveillance, tailored therapies, and interdisciplinary care models are essential for enhancing survivors’ quality of life.