Scholarlink

Background <p>Severe hypercapnia, especially when associated with acidosis, should be avoided or actively managed, as it is an independent risk factor in critically ill patients. The ADVOS multi hemodialysis system offers the potential to correct acidosis and hypercapnia through customizable pH and bicarbonate content within the dialysate fluid. The aim of this work is to analyze the exact timing for pH correction and the main factors leading to it in patients with multiple organ failure (MOF) and hypercapnic acidosis treated with ADVOS.</p> Methods <p>Patients with MOF and metabolic or hypercapnic acidosis (pH &lt; 7.35) were included over a study period of 13&#xa0;months. All patients received at least one treatment with ADVOS hemodialysis system for at least 24&#xa0;h. The primary outcome was the time to blood pH ≥ 7.35.</p> Results <p>24 patients with a median age of 61&#xa0;years and a median SOFA score of 15 points were included. The results of 134 ADVOS sessions, with a median of 5 sessions per patient, were analyzed. Median time to blood pH ≥ 7.35 was 4&#xa0;h; a significant blood pH increase within 24&#xa0;h was reached in all patients (7.21 before vs. 7.39 after, <i>p</i> &lt; 0.01).</p> Conclusions <p>A single session of ADVOS corrected blood pH and supported the reduction of pCO<sub>2</sub> with a median CO<sub>2</sub> removal of 55&#xa0;mL/min in patients with multiple organ failure and hypercapnic acidosis.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The ADVanced Organ Support (ADVOS) hemodialysis system balances blood pH within 24 h in patients with multiple organ failure and hypercapnic acidosis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月25日

查看全文
  • Miriam Dibos,
  • Aritz Perez Ruiz de Garibay,
  • Ulrich Mayr,
  • Roland M. Schmid,
  • Johannes Honigschnabel,
  • Tobias Lahmer

摘要

Background

Severe hypercapnia, especially when associated with acidosis, should be avoided or actively managed, as it is an independent risk factor in critically ill patients. The ADVOS multi hemodialysis system offers the potential to correct acidosis and hypercapnia through customizable pH and bicarbonate content within the dialysate fluid. The aim of this work is to analyze the exact timing for pH correction and the main factors leading to it in patients with multiple organ failure (MOF) and hypercapnic acidosis treated with ADVOS.

Methods

Patients with MOF and metabolic or hypercapnic acidosis (pH < 7.35) were included over a study period of 13 months. All patients received at least one treatment with ADVOS hemodialysis system for at least 24 h. The primary outcome was the time to blood pH ≥ 7.35.

Results

24 patients with a median age of 61 years and a median SOFA score of 15 points were included. The results of 134 ADVOS sessions, with a median of 5 sessions per patient, were analyzed. Median time to blood pH ≥ 7.35 was 4 h; a significant blood pH increase within 24 h was reached in all patients (7.21 before vs. 7.39 after, p < 0.01).

Conclusions

A single session of ADVOS corrected blood pH and supported the reduction of pCO2 with a median CO2 removal of 55 mL/min in patients with multiple organ failure and hypercapnic acidosis.