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<p>Sepsis and septic shock remain a global health challenge with high mortality and long-term morbidity. Contemporary evidence highlights immune dysregulation, endothelial dysfunction, and glycocalyx degradation as key pathophysiological drivers. Clinical management has evolved from uniform approaches to precision-guided strategies that integrate subphenotyping, biomarkers and novel therapies. This review synthesizes data from guidelines, translational research, and clinical trials to provide a comprehensive perspective on current management and future directions in sepsis care.</p>

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Update on sepsis treatment

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月1日

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  • Luis Chiscano-Camon,
  • Juan Carlos Ruiz-Rodríguez,
  • Adolf Ruiz-Sanmartin,
  • Pablo Nicolas-Morales,
  • Manuel Hernandez-Gonzalez,
  • Ricard Ferrer

摘要

Sepsis and septic shock remain a global health challenge with high mortality and long-term morbidity. Contemporary evidence highlights immune dysregulation, endothelial dysfunction, and glycocalyx degradation as key pathophysiological drivers. Clinical management has evolved from uniform approaches to precision-guided strategies that integrate subphenotyping, biomarkers and novel therapies. This review synthesizes data from guidelines, translational research, and clinical trials to provide a comprehensive perspective on current management and future directions in sepsis care.