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<p>In this comment, we aim to provide a perspective on the study by Shvilkina et al. entitled “Echocardiographic phenotypes in sepsis: identifying subgroups using latent profile analysis”. After summarizing the principal findings, we discuss several issues related to the interpretation of cluster-based phenotypes. These considerations highlight important methodological limitations that may influence the validity and clinical applicability of the proposed phenotypes.</p>

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Comment on: Echocardiographic phenotypes in sepsis: identifying subgroups using latent profile analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月6日

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  • Ngan Hoang Kim Trieu,
  • Thanh Luan Nguyen

摘要

In this comment, we aim to provide a perspective on the study by Shvilkina et al. entitled “Echocardiographic phenotypes in sepsis: identifying subgroups using latent profile analysis”. After summarizing the principal findings, we discuss several issues related to the interpretation of cluster-based phenotypes. These considerations highlight important methodological limitations that may influence the validity and clinical applicability of the proposed phenotypes.