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<p>A recent meta-analysis of randomized controlled trials (with pre-specified methods and the largest sample to date) found that prophylactic diuretics significantly reduce acute kidney injury (AKI) incidence in high-risk patients but provide no benefit in treating established AKI. These findings challenge current AKI management guidelines, which generally discourage prophylactic diuretic use. However, given heterogeneity among trials and some risk of bias, caution is advised before generally altering clinical practice until further research confirms these findings.</p>

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Rethinking diuretic use in acute kidney injury: effective prevention or false hope?

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月16日

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  • Hiroyuki Yamada,
  • Maki Murata,
  • Hiroyuki Hashimoto

摘要

A recent meta-analysis of randomized controlled trials (with pre-specified methods and the largest sample to date) found that prophylactic diuretics significantly reduce acute kidney injury (AKI) incidence in high-risk patients but provide no benefit in treating established AKI. These findings challenge current AKI management guidelines, which generally discourage prophylactic diuretic use. However, given heterogeneity among trials and some risk of bias, caution is advised before generally altering clinical practice until further research confirms these findings.