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Objectives <p>This study explores <i>Russelia equisetiformis</i> as a sustainable source for the green synthesis of antifungal nanomaterials. In response to increasing phytopathogenic fungi and environmental issues, it focuses on the fabrication of manganese nanoparticles (MnONPs), nitrogen-doped carbon dots (<i>N</i>-CDs), and their nanocomposite (MnO NPs@N-CDs) using <i>R. equisetiformis</i> extract.</p> Methods <p>The synthesized nanomaterials were characterized by UV–Vis spectrophotometry, FTIR, DLS, TEM, and EDX to confirm nanoparticle formation. Their antifungal effectiveness was evaluated against <i>Sclerotinia sclerotiorum, Fusarium equiseti</i>, and <i>Fusarium venenatum</i>. Additionally, bioactive metabolites were identified via LC–QTOF-MS, and their antifungal activity, pharmacokinetic profiles, and toxicity levels were assessed through computational tools.</p> Results <p>Nanomaterials produced from <i>R. equisetiformis</i> extract significantly reduced fungal growth, highlighting their potential as eco-friendly solutions for plant disease control. Most metabolites exhibited favorable safety profiles with minimal predicted cardiotoxicity and mutagenicity, indicating their promise as safe fungicides.</p> Conclusion <p><i>R. equisetiformis</i> provides compounds with effective antifungal activity and low toxicity, offering a promising, environmentally friendly alternative to conventional chemical fungicides for sustainable plant disease management. Further research is essential to expand their application in agriculture.</p> Graphical Abstract <p></p>

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Metabolite detection via QTOF-LCMS and computational analysis on Russelia equisetiformis exploring green nanotechnology and antifungal against phytopathogens

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月9日

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  • Reham M. Aldahasi,
  • Sahar S. Alghamdi,
  • Nouf Albulushi,
  • Hanin Alhuraibi,
  • Rasha Saad Suliman,
  • Arwa Alsubait,
  • Amirah S. Alahmari,
  • Afrah E. Mohammed

摘要

Objectives

This study explores Russelia equisetiformis as a sustainable source for the green synthesis of antifungal nanomaterials. In response to increasing phytopathogenic fungi and environmental issues, it focuses on the fabrication of manganese nanoparticles (MnONPs), nitrogen-doped carbon dots (N-CDs), and their nanocomposite (MnO NPs@N-CDs) using R. equisetiformis extract.

Methods

The synthesized nanomaterials were characterized by UV–Vis spectrophotometry, FTIR, DLS, TEM, and EDX to confirm nanoparticle formation. Their antifungal effectiveness was evaluated against Sclerotinia sclerotiorum, Fusarium equiseti, and Fusarium venenatum. Additionally, bioactive metabolites were identified via LC–QTOF-MS, and their antifungal activity, pharmacokinetic profiles, and toxicity levels were assessed through computational tools.

Results

Nanomaterials produced from R. equisetiformis extract significantly reduced fungal growth, highlighting their potential as eco-friendly solutions for plant disease control. Most metabolites exhibited favorable safety profiles with minimal predicted cardiotoxicity and mutagenicity, indicating their promise as safe fungicides.

Conclusion

R. equisetiformis provides compounds with effective antifungal activity and low toxicity, offering a promising, environmentally friendly alternative to conventional chemical fungicides for sustainable plant disease management. Further research is essential to expand their application in agriculture.

Graphical Abstract