Hypoglycemic effects of dracorhodin and dragon blood crude extract from Daemonorops draco

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2024年3月6日

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Yung-Hao Ching,
Fang-Mei Lin,
Hong-Chi Chen,
Ching-Yun Hsu,
Sze Yen P’ng,
Tai-No Lin,
Yu-Chia Wang,
Cheng-Jun Lin,
Yi-Chi Chen,
Tsung-Jung Ho,
Hao-Ping Chen

摘要

Background

Dragon blood is a red fruit resin from the palm tree Daemonorops draco and is a herbal ingredient used in the traditional Chinese medicine, “Jinchuang Ointment,” which is used to treat non-healing diabetic wounds. According to the Taiwan Herbal Pharmacopeia, the dracorhodin content in dragon blood should exceed 1.0%.

Results

Our findings indicate that dracorhodin and dragon blood crude extracts can stimulate glucose uptake in mouse muscle cells (C2C12) and primary rat aortic smooth muscle cells (RSMC). Dracorhodin is not the only active compound in dragon blood crude extracts from D. draco. Next, we orally administered crude dragon blood extracts to male B6 mice. The experimental group displayed a decreasing trend in fasting blood glucose levels from the second to tenth week. In summary, crude extracts of dragon blood from D. draco demonstrated in vivo hypoglycemic effects in B6 male mice.

Conclusions

We provide a scientific basis “Jinchuang ointment” in treating non-healing wounds in patients with diabetes.