Scholarlink

<p>Chordoid is a rare WHO grade 2 meningioma subtype with unpredictable clinical behavior. This study evaluated the prognostic significance of chromosomes 1p and 22q deletions, DNA methylation-based classification, and immunohistochemical expression of ACADL, MCM2, and H3 K27me3 in 44 chordoid meningiomas to assess whether these factors can be used to improve the stratification of these tumors. Deletion of chromosome 1p was detected in 53% of cases and was significantly associated with tumor recurrence and shorter recurrence-free survival (RFS). The concurrent deletion of 1p and 22q was further correlated with poorer outcomes and remained an independent prognostic factor in the multivariate analysis. MCM2 expression was also linked to higher recurrence rates and reduced RFS, whereas DNA methylation classes and H3 K27me3 expression showed no prognostic relevance in this study. These findings support the use of 1p/22q copy number status and MCM2 immunohistochemistry for improved prognostic stratification of chordoid meningiomas, whereas DNA methylation profiling and H3 K27me3 assessment appear less informative for this subtype.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Prognostic stratification of chordoid meningiomas: the role of chromosome 1p/22q Loss

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月6日

查看全文
  • Rosina Paterra,
  • Matteo Zago,
  • Fabio Agistri,
  • Gonzalo Hernandez Gamero,
  • Andrea Mafficini,
  • Serena Pedron,
  • Arianna Berlendis,
  • Filippo Nozzoli,
  • Francesco Di Meco,
  • Valeria Barresi

摘要

Chordoid is a rare WHO grade 2 meningioma subtype with unpredictable clinical behavior. This study evaluated the prognostic significance of chromosomes 1p and 22q deletions, DNA methylation-based classification, and immunohistochemical expression of ACADL, MCM2, and H3 K27me3 in 44 chordoid meningiomas to assess whether these factors can be used to improve the stratification of these tumors. Deletion of chromosome 1p was detected in 53% of cases and was significantly associated with tumor recurrence and shorter recurrence-free survival (RFS). The concurrent deletion of 1p and 22q was further correlated with poorer outcomes and remained an independent prognostic factor in the multivariate analysis. MCM2 expression was also linked to higher recurrence rates and reduced RFS, whereas DNA methylation classes and H3 K27me3 expression showed no prognostic relevance in this study. These findings support the use of 1p/22q copy number status and MCM2 immunohistochemistry for improved prognostic stratification of chordoid meningiomas, whereas DNA methylation profiling and H3 K27me3 assessment appear less informative for this subtype.