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<p>Complex crosstalk occurs between protein and nucleic acid modifications, with lactylation, an emerging post-translational modification (PTM), being implicated in tumor progression. However, the mechanisms mediating the crosstalk between lactylation and RNA modifications and their roles in disease pathogenesis remain largely unresolved. In this review, we summarize current advances in the regulatory interactions between lactylation and RNA modifications, explore their functional implications in cancer biology, and discuss the therapeutic potential of targeting these modifications individually or in combination. This work aims to provide a comprehensive overview of their mechanistic involvement in cancer and to inform novel strategies for precision-targeted therapy.</p>

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Crosstalk between lactylation and RNA modifications in tumorigenesis: mechanisms and therapeutic implications

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月26日

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  • Shantong Liu,
  • Qianquan Ma,
  • Chong Zeng,
  • Haoyu Li,
  • Jun Su,
  • Zhihao Song,
  • Ruyu Yan,
  • Zijin Zhao,
  • Songhai Tian,
  • Wei Huang

摘要

Complex crosstalk occurs between protein and nucleic acid modifications, with lactylation, an emerging post-translational modification (PTM), being implicated in tumor progression. However, the mechanisms mediating the crosstalk between lactylation and RNA modifications and their roles in disease pathogenesis remain largely unresolved. In this review, we summarize current advances in the regulatory interactions between lactylation and RNA modifications, explore their functional implications in cancer biology, and discuss the therapeutic potential of targeting these modifications individually or in combination. This work aims to provide a comprehensive overview of their mechanistic involvement in cancer and to inform novel strategies for precision-targeted therapy.