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Background <p>Inflammation and oxidative stress are key risk factors in noncommunicable diseases (NCDs). Probiotics have been suggested to be beneficial in mitigating inflammation and oxidative stress; however, the evidence remains inconsistent due to variations in study design, dosage, and patient populations.</p> Methods <p>Studies were included following a systematic search of PubMed, Scopus, Cochrane Library, Web of Science, and EMBASE, provided they fulfilled the eligibility criteria. This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to clarify the effects of probiotics on oxidative stress and inflammation in non-communicable diseases (NCDs).</p> Results <p>A review of 18 studies revealed that probiotic supplementation significantly reduced CRP (SMD = -1.33, 95% CI: -1.84, -0.82; <i>p</i> &lt; 0.001, high certainty), TNF-α (SMD = -1.10, 95% CI: -1.66, -0.55; <i>p</i> &lt; 0.001, low certainty), and MDA levels (SMD = -1.38, 95% CI: -2.08, -0.69; <i>p</i> &lt; 0.001, high certainty). Additionally, while probiotics increased GSH levels (SMD = 0.65, 95% CI: 0.06, 1.23; <i>p</i> &lt; 0.001, high certainty), they did not change the levels of IL-6 (SMD = -1.05, 95% CI: -2.21, 0.11; <i>p</i> &lt; 0.001, low certainty), NO (SMD = 0.47, 95% CI: -0.54, 1.48; <i>p</i> = 0.363, low certainty) and TAC levels (SMD = 0.24, 95% CI: -0.27, 0.74; <i>p</i> = 0.357, moderate certainty).</p> Conclusion <p>The supplementation of probiotics may have mitigated biomarkers associated with inflammation and oxidative stress.</p>

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Alleviating effects of probiotic supplementation on biomarkers of inflammation and oxidative stress in non-communicable diseases: a systematic review and meta-analysis using the GRADE approach

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Xiaoyuan Yu,
  • Li Yan,
  • Lingxiao Chen,
  • Xianmei Shen,
  • Wenzheng Zhang

摘要

Background

Inflammation and oxidative stress are key risk factors in noncommunicable diseases (NCDs). Probiotics have been suggested to be beneficial in mitigating inflammation and oxidative stress; however, the evidence remains inconsistent due to variations in study design, dosage, and patient populations.

Methods

Studies were included following a systematic search of PubMed, Scopus, Cochrane Library, Web of Science, and EMBASE, provided they fulfilled the eligibility criteria. This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to clarify the effects of probiotics on oxidative stress and inflammation in non-communicable diseases (NCDs).

Results

A review of 18 studies revealed that probiotic supplementation significantly reduced CRP (SMD = -1.33, 95% CI: -1.84, -0.82; p < 0.001, high certainty), TNF-α (SMD = -1.10, 95% CI: -1.66, -0.55; p < 0.001, low certainty), and MDA levels (SMD = -1.38, 95% CI: -2.08, -0.69; p < 0.001, high certainty). Additionally, while probiotics increased GSH levels (SMD = 0.65, 95% CI: 0.06, 1.23; p < 0.001, high certainty), they did not change the levels of IL-6 (SMD = -1.05, 95% CI: -2.21, 0.11; p < 0.001, low certainty), NO (SMD = 0.47, 95% CI: -0.54, 1.48; p = 0.363, low certainty) and TAC levels (SMD = 0.24, 95% CI: -0.27, 0.74; p = 0.357, moderate certainty).

Conclusion

The supplementation of probiotics may have mitigated biomarkers associated with inflammation and oxidative stress.