Objective <p>To study the efficacy of sucroferric oxyhydroxide (SFOH) and lanthanum carbonate (LC) in the treatment of hemodialysis hyperphosphatemia.</p> Methods <p>A total of 60 hemodialysis patients with secondary hyperparathyroidism combined with hyperphosphatemia from January 2024 to April 2024 in China Rongtong Medical &amp; Healthcare Group Tai’an 88 Hospital were selected. All patients were randomly divided into 2 groups. One group was treated with SFOH, and the other with LC. Patients in the 2 groups were treated for 3 months continuously, and clinical outcomes, serum phosphorus, serum calcium, and intact parathyroid hormone (iPTH) levels were compared before treatment, and at 1, 2, and 3 months after treatment.</p> Results <p>When compared with before treatment, the serum phosphorus levels of both groups of patients decreased significantly after 1 month, 2 months, and 3 months of treatment, with statistical significance (<i>P</i> &lt; 0.01). The degree of serum phosphorus decrease in SFOH group was higher than that in LC group (<i>P</i> &lt; 0.01, <i>P</i> &lt; 0.05). There was no statistically significant difference in the effect of serum calcium between the two groups (<i>P</i> &gt; 0.05). Both groups of patients showed a significant decrease in iPTH after treatment, with a statistically significant difference (<i>P</i> &lt; 0.01). The degree of iPTH decrease in SFOH group was more pronounced than in LC group (<i>P</i> &lt; 0.05). After treatment, the serum hosphorus compliance rates of SFOH group and LC Group were 80% and 53.3%, respectively, and the difference in effective rates between the two groups was statistically significant (<i>P</i> &lt; 0.05).</p> Conclusion <p>SFOH was superior to LC in lowering patients’ blood phosphorus and iPTH levels in patients with maintenance hemodialysis hyperphosphatemia combined with secondary hyperparathyroidism.</p>