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Background <p>Epoetin alfa is a derivative of the erythropoietin hormone. This study aims to investigate the epoetin alfa effect on anxiety-like behaviors.</p> Methods <p>Adult female Wistar Albino rats were divided into Control (<i>n</i> = 8), 1000&#xa0;U Epoetien alfa, and 2000&#xa0;U Epoetien alpha. Epoetin alfa was administered intraperitoneally once a week for 4&#xa0;weeks. The animals were then subjected to open field test, elevated plus maze, light-dark box, and the behaviors were video recorded.</p> Results <p>Epoetin alfa significantly reduced anxiety-like behaviors in both low- and high-dose groups in a dose-independent manner. This anxiolytic effect was seen in all three anxiety tests. Further, exploratory behaviors such as unsupported rearing and head-dipping behaviors increased with the application of Epoetin alfa. This protocol did not alter locomotor activity.</p> Conclusion <p>The present study found beneficial effects of epoetin alfa on behaviors. Further studies on the effect of derivatives of erythropoietin hormone on anxiety-like behaviors are needed.</p>

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Epoetin alfa has a potent anxiolytic effect on naive female rats

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月28日

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  • Hasan Çalışkan,
  • Seda Koçak,
  • Emel Güneş

摘要

Background

Epoetin alfa is a derivative of the erythropoietin hormone. This study aims to investigate the epoetin alfa effect on anxiety-like behaviors.

Methods

Adult female Wistar Albino rats were divided into Control (n = 8), 1000 U Epoetien alfa, and 2000 U Epoetien alpha. Epoetin alfa was administered intraperitoneally once a week for 4 weeks. The animals were then subjected to open field test, elevated plus maze, light-dark box, and the behaviors were video recorded.

Results

Epoetin alfa significantly reduced anxiety-like behaviors in both low- and high-dose groups in a dose-independent manner. This anxiolytic effect was seen in all three anxiety tests. Further, exploratory behaviors such as unsupported rearing and head-dipping behaviors increased with the application of Epoetin alfa. This protocol did not alter locomotor activity.

Conclusion

The present study found beneficial effects of epoetin alfa on behaviors. Further studies on the effect of derivatives of erythropoietin hormone on anxiety-like behaviors are needed.