Objective <p>The purpose of this study is to investigate the association between psychological well-being and perceived stress, resilience, life project, and emotion regulation of Syrian refugees affected by the COVID-19 outbreak.</p> Methods <p>In the study, 520 Syrian refugee adults aged between 25–50 were included in the sample. The participants in the research sample are predominantly male (62.5%). Demographic Information Form, Psychological Well-Being Scale, Psychological Resilience Scale, Emotion Regulation Difficulty Scale, and Perceived Stress Factor scale were applied to participants as data collection tools.</p> Results <p>In this study, correlation and hierarchical regression analyses were conducted. The correlation analysis revealed moderately significant relations between the variables. Psychological well-being was positively predicted by psychological resilience, Emotion Regulatory Aims, and Hope in a four-stage hierarchical regression analysis aimed at identifying the variables associated with psychological well-being. Conversely, Regret and Emotion Regulatory Difficulty, determined by Openness, Rejection, and Perceived Insufficient Self-efficacy, were predicted in a negative manner.</p> Conclusion <p>“The findings suggest that resilience-building strategies and support for ontological well-being may be associated with higher levels of psychological well-being among refugees. Additionally, perceived stress was negatively with psychological well-being. These cross-sectional findings highlight the potential relevance of psychological resilience, ontological well-being, emotion regulation, and perceived stress for future intervention research, though causal inferences cannot be drawn from the present design.</p>