Background <p>Refugees usually face stressful events both in the destination country and during migration. To date, no tool has been designed to reflect the post-migration stress of Persian-speaking refugees on the basis of their current life conditions. Therefore, this study was conducted to determine the psychometric characteristics of the Persian version of the Refugee Post-migration Stress Scale (RPMS).</p> Methodology <p>This cross-sectional study was conducted in 2022 with 355 Iranian refugees in Turkey. The original RPMS includes 21 items and 7 subscales. First, the original version of the tool was translated into Farsi via the standard forward-backward method. The instrument’s validity was checked through face validity, content validity, and construct validity via confirmatory factor analysis (CFA) and convergent validity with the World Health Organization-Five Well-Being Index <b>(</b>WHO-5) and the Hopkins Symptom Checklist 25 (HSCL-25(. Reliability was evaluated via the internal consistency method (Cronbach’s alpha). SPSS version 16 and LISREL version 8.8 software packages were used for data analysis.</p> Results <p>Face validity and content validity were confirmed by refugees and experts with slight changes. CFA revealed that the proposed 7-subscale model of the original RPMS has a good fit (RMSEA: 0.08, NFI: 0.92; CFI: 0.95; IFI: 0.95; GFI 0.86; SRMR: 0.06). The convergent validity results also showed that the studied instrument has a suitable structure. Convergent validity was confirmed via the Pearson correlation results between the RPMS and two instruments: the HSCL-25 (<i>p</i> &lt; 0.001, <i>r</i> = 0.33) and the WHO-5 (<i>p</i> &lt; 0.001, <i>r</i>= -0.30). Additionally, the Cronbach’s alpha coefficient was 0.88.</p> Conclusion <p>According to the psychometric results of the tool in the Persian-speaking refugee population, the tool is appropriate for measuring post-migration stress in refugees. Another advantage of this tool is its brevity and shortness.</p>