Background <p>This study aimed to translate the Caregiver Task Inventory-45 (CTI-45) into Mandarin and evaluate its psychometric properties for use among family caregivers of stroke survivors in China.</p> Methods <p>This methodological study included cognitive interviews and a psychometric evaluation of the CTI-45. Questionnaires were distributed to family caregivers at four tertiary hospitals in Tianjin, China. In addition to the eight family caregivers who participated in the cognitive interviews, 251 family caregivers of stroke survivors aged ≥ 18 years, who were biologically or legally related to the survivors, were providing unpaid home care, and were proficient in Mandarin, completed the survey. The CTI-45 was translated according to the European Organisation for Research and Treatment of Cancer (EORTC) translation protocol. Cognitive interviews were then conducted to evaluate the Mandarin CTI-45 using ordinal confirmatory factor analysis (CFA). The suggested one- and three-factor models were both evaluated. Internal consistency reliability was assessed using ordinal alpha and ordinal omega coefficients.</p> Results <p>The suggested three-factor model was superior compared to the one-factor model and demonstrated acceptable model fit (RMSEA = 0.042, CFI = 0.996, TLI = 0.995, SRMR = 0.072). All three scales demonstrated excellent reliability according to ordinal alpha and ordinal omega: Direct care to the patient 0.96/0.92, Intrapersonal tasks 0.97/0.94, and Interpersonal ties 0.95/0.90.</p> Conclusions <p>The Mandarin version of the CTI-45 demonstrated good psychometric properties and could be used to assess the multidimensional care needs of family caregivers caring for stroke survivors.</p>