Objective <p>Assess the effect of fear of cancer recurrence (FCR) and coping strategies on patients with oral cancer’s post-traumatic growth (PTG).</p> Methods <p>A total of 255 patients with oral cancer participated and were investigated using the Chinese version of the Posttraumatic Growth Inventory (PTGI), the Fear of Progression Questionnaire-Short Form (FOP-Q-SF), and the Simplified Coping Style Questionnaire (SCSQ) in this cross-sectional study. Descriptive, univariate, Pearson correlation analyses, and multiple linear regression analyses were performed.</p> Results <p>Higher FCR scores were negatively associated with PTG (<i>r</i> = -0.646). Negative coping strategies were negatively correlated with PTG (<i>r</i> = -0.219). Positive coping strategies positively correlated with PTG (<i>r</i> = 0.482). Regression analysis indicated that the treatment of surgery combined with chemotherapy and radiotherapy, FCR, and coping strategies had significant independent influences on patients with oral cancer’s PTG.</p> Conclusions <p>Reducing fear of recurrence and improving one’s capacity for proactive coping in the face of traumatic situations are necessary for post-traumatic growth stimulation. Thus, it is important to develop and implement focused therapies aimed at enhancing post-traumatic growth in patients with oral cancer.</p>