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Background <p>Respiratory distress and COVID-19-related symptoms persist as Post-COVID-19 syndrome (PCS) in a proportion of children and adolescents.</p> <p>We aimed to determine whether ventilation or perfusion defects constitute a possible cause for PCS.</p> Results <p>Mean ventilation was lower at baseline in vaccinated than in PCS (p=0.04) and V/Qmatchnon-defected increased from baseline to follow-up in vaccinated (p=0.03). In post-hoc comparison with historic data, V/Qmatchnon-defected improved in recovered (historic: 63.5±18.7%; baseline: 88.8±9.0%, p&lt;0.0001; follow-up: 88.1±10.6%; p=0.0002) and PCS (historic: 57.3±19.5%; baseline: 86.1±7.6%, p&lt;0.0001; follow-up: 86.6±7.7%, p=0.0110). Symptom load in PCS decreased from infection and baseline time points to 6-month follow-up. Laboratory assessments showed no differences. </p> Conclusion <p>Despite persisting clinical symptoms, PREFUL MRI demonstrates no significant difference between cohorts, not supporting the hypothesis of persisting defects of the lung as causative. </p>

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Longitudinal functional lung imaging in children with Post-COVID-19 syndrome

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月31日

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  • Calvin Kraus,
  • Lina Tan,
  • Maximilian Hinsen,
  • Sandy Schmidt,
  • Emmanuel Nedoschill,
  • Felix Wachter,
  • Henriette Mandelbaum,
  • Alexandra L. Wagner,
  • Isabelle Schöffl,
  • Annika Weigelt,
  • Manfred Rauh,
  • Joachim Woelfle,
  • Michael Uder,
  • Regina Trollmann,
  • Jens Vogel-Claussen,
  • Adrian P. Regensburger,
  • Rafael Heiss,
  • Ferdinand Knieling,
  • Roman Raming

摘要

Background

Respiratory distress and COVID-19-related symptoms persist as Post-COVID-19 syndrome (PCS) in a proportion of children and adolescents.

We aimed to determine whether ventilation or perfusion defects constitute a possible cause for PCS.

Results

Mean ventilation was lower at baseline in vaccinated than in PCS (p=0.04) and V/Qmatchnon-defected increased from baseline to follow-up in vaccinated (p=0.03). In post-hoc comparison with historic data, V/Qmatchnon-defected improved in recovered (historic: 63.5±18.7%; baseline: 88.8±9.0%, p<0.0001; follow-up: 88.1±10.6%; p=0.0002) and PCS (historic: 57.3±19.5%; baseline: 86.1±7.6%, p<0.0001; follow-up: 86.6±7.7%, p=0.0110). Symptom load in PCS decreased from infection and baseline time points to 6-month follow-up. Laboratory assessments showed no differences.

Conclusion

Despite persisting clinical symptoms, PREFUL MRI demonstrates no significant difference between cohorts, not supporting the hypothesis of persisting defects of the lung as causative.