Scholarlink

Background <p>Growing evidence indicates that bulimia nervosa (BN) is more likely driven by network-level dysfunctions rather than abnormalities in isolated brain regions. However, previous studies focusing on specific regions or connectivity features have led to a limited understanding of the complexity and integrality of network in BN. This study aimed to investigate large- and mesoscale network alterations in BN from the perspective of network segregation and integration.</p> Methods <p>Using resting-state functional magnetic resonance imaging data from 85 BN patients and 71 healthy controls (HCs) matched for age, sex, and education, we applied a graph-theoretic framework to analyze functional network architecture in BN. Specifically, we examined group differences in within- and between-system functional connectivity (FC) as well as system segregation at both the whole-brain and system levels. Associations between network measures and clinical features were further explored.</p> Results <p>Compared with HCs, BN patients exhibited whole-brain reduced within- and between-system FC accompanied by increased system segregation. At the system level, patients showed increased between-system FC of the default mode network (DMN), control network and ventral attention network, along with decreased DMN system segregation. The increased integration of DMN with other systems was associated with higher Beck Depression Inventory (BDI-21) scores in BN patients.</p> Conclusions <p>The neural mechanisms of BN involve an imbalance between network segregation and integration at both global and system levels, most pronounced within the DMN, whose alterations are associated with depression and disordered eating behavior. These findings may provide potential neural substrates for some core behavioral deficits in BN.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Aberrant large- and mesoscale network segregation and integration in bulimia nervosa

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月23日

查看全文
  • Peng Zhang,
  • Lirong Tang,
  • Weihua Li,
  • Miao Wang,
  • Yulong Jia,
  • Fengxia Yu,
  • Zhanjiang Li,
  • Zhenchang Wang,
  • Jiani Wang,
  • Guowei Wu,
  • Yiling Wang

摘要

Background

Growing evidence indicates that bulimia nervosa (BN) is more likely driven by network-level dysfunctions rather than abnormalities in isolated brain regions. However, previous studies focusing on specific regions or connectivity features have led to a limited understanding of the complexity and integrality of network in BN. This study aimed to investigate large- and mesoscale network alterations in BN from the perspective of network segregation and integration.

Methods

Using resting-state functional magnetic resonance imaging data from 85 BN patients and 71 healthy controls (HCs) matched for age, sex, and education, we applied a graph-theoretic framework to analyze functional network architecture in BN. Specifically, we examined group differences in within- and between-system functional connectivity (FC) as well as system segregation at both the whole-brain and system levels. Associations between network measures and clinical features were further explored.

Results

Compared with HCs, BN patients exhibited whole-brain reduced within- and between-system FC accompanied by increased system segregation. At the system level, patients showed increased between-system FC of the default mode network (DMN), control network and ventral attention network, along with decreased DMN system segregation. The increased integration of DMN with other systems was associated with higher Beck Depression Inventory (BDI-21) scores in BN patients.

Conclusions

The neural mechanisms of BN involve an imbalance between network segregation and integration at both global and system levels, most pronounced within the DMN, whose alterations are associated with depression and disordered eating behavior. These findings may provide potential neural substrates for some core behavioral deficits in BN.