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Background <p>Schistosomiasis, a snail-borne parasitic disease of public health and veterinary importance in tropical areas, is highly prevalent in sub-Saharan Africa, particularly in West Africa. The World Health Organization (WHO) has established ambitious goals of eliminating schistosomiasis as public health problem or interrupting its transmission by 2030. The zoonotic transmission of schistosomiasis involving nonhuman mammals (NHMs) complicates disease endemicity and hinders the attainment of these objectives. This study synthesized recent trends and the prevalence of human-infective schistosomes (HISs), including&#xa0;<i>Schistosoma mansoni</i>,&#xa0;<i>S. haematobium</i>,&#xa0;<i>S. haematobium</i> × <i>S. bovis</i>&#xa0;hybrids,&#xa0;<i>S. guineensis</i>, and&#xa0;<i>S. intercalatum</i>—across 16 West African countries.</p> Methods <p>We conducted a systematic literature search from March 25 to April 30, 2025, across PubMed, Scopus, Embase, and Web of Science, to identify studies on HISs (<i>S. mansoni</i>,&#xa0;<i>S. haematobium</i>,&#xa0;<i>S. haematobium</i> × <i>S. bovis</i>,&#xa0;<i>S. guineensis</i>, and&#xa0;<i>S. intercalatum</i>) in NHMs in western Africa. In addition, we manually searched African Journal Online (AJOL) and screened the references of the included articles. The data were organized in Microsoft Excel 2021 and analyzed via GraphPad Prism to identify publication trends, NHM infection incidence, and species-specific positivity rates (with 95% <i>CIs</i>). The spatial distribution of HIS-infected NHMs was visualized with QGIS to pinpoint high-risk areas.</p> Results <p>Four countries (Benin, Ghana, Nigeria, and Senegal) reported cases of HIS infection in NHMs with an overall prevalence of 8% (95% <i>CI</i>: 7–9%). Benin had the highest proportion of infected hosts (50%, 95% <i>CI</i>: 40–60%) and Senegal had the lowest proportion (5%, 95% <i>CI</i>: 4–6%). <i>Bos taurus</i>&#xa0;(60% prevalence) was the most affected species and served as a reservoir for <i>S. haematobium</i> × <i>S. bovis</i> hybrids, whereas&#xa0;<i>S. mansoni</i>&#xa0;exhibited an extensive distribution among rodent and primate hosts.</p> Conclusion <p>For effective elimination, integrated control strategies—spanning NHM surveillance, snail intermediate host monitoring, and human mass drug administration—must be prioritized. Policy reforms should address zoonotic transmission risks, particularly in high-prevalence zones, to align interventions with the complex ecology of schistosomiasis in West Africa.</p> Graphical abstract <p></p>

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A reservoir at the gates: nonhuman mammalian hosts for human schistosomiasis in western Africa and the critical challenge for elimination

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月12日

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  • Benjamin Sanogo,
  • Isaac Echoru,
  • Caitlin Jones,
  • Caitlin Butala,
  • Datao Lin,
  • Hamma Maiga,
  • Hugo Sámano-Sánchez,
  • Moussa Sacko,
  • Kokouvi Kassegne,
  • Susan Christina Welburn

摘要

Background

Schistosomiasis, a snail-borne parasitic disease of public health and veterinary importance in tropical areas, is highly prevalent in sub-Saharan Africa, particularly in West Africa. The World Health Organization (WHO) has established ambitious goals of eliminating schistosomiasis as public health problem or interrupting its transmission by 2030. The zoonotic transmission of schistosomiasis involving nonhuman mammals (NHMs) complicates disease endemicity and hinders the attainment of these objectives. This study synthesized recent trends and the prevalence of human-infective schistosomes (HISs), including Schistosoma mansoni, S. haematobium, S. haematobium × S. bovis hybrids, S. guineensis, and S. intercalatum—across 16 West African countries.

Methods

We conducted a systematic literature search from March 25 to April 30, 2025, across PubMed, Scopus, Embase, and Web of Science, to identify studies on HISs (S. mansoni, S. haematobium, S. haematobium × S. bovis, S. guineensis, and S. intercalatum) in NHMs in western Africa. In addition, we manually searched African Journal Online (AJOL) and screened the references of the included articles. The data were organized in Microsoft Excel 2021 and analyzed via GraphPad Prism to identify publication trends, NHM infection incidence, and species-specific positivity rates (with 95% CIs). The spatial distribution of HIS-infected NHMs was visualized with QGIS to pinpoint high-risk areas.

Results

Four countries (Benin, Ghana, Nigeria, and Senegal) reported cases of HIS infection in NHMs with an overall prevalence of 8% (95% CI: 7–9%). Benin had the highest proportion of infected hosts (50%, 95% CI: 40–60%) and Senegal had the lowest proportion (5%, 95% CI: 4–6%). Bos taurus (60% prevalence) was the most affected species and served as a reservoir for S. haematobium × S. bovis hybrids, whereas S. mansoni exhibited an extensive distribution among rodent and primate hosts.

Conclusion

For effective elimination, integrated control strategies—spanning NHM surveillance, snail intermediate host monitoring, and human mass drug administration—must be prioritized. Policy reforms should address zoonotic transmission risks, particularly in high-prevalence zones, to align interventions with the complex ecology of schistosomiasis in West Africa.

Graphical abstract