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Background <p>The mosquito’s gut microbiota plays a crucial role in determining its capacity to transmit harmful viruses and parasites. Accordingly, manipulating mosquito gut microbiota is a promising avenue for reducing the transmission of&#xa0;mosquito-borne human pathogens. A successful microbial control campaign will require a thorough understanding of how bacteria are transmitted within mosquito populations. In two parallel but complementary studies using the yellow fever mosquito <i>Aedes</i> <i>aegypti</i> as a focal host species, we surveyed the&#xa0;vertical transmission of bacteria from individual mothers to cohorts of offspring maintained in a closed system.</p> Results <p>Laboratory- and field-derived mothers deposited bacteria that support offspring development, and the relative abundances of commonly transmitted taxa correlated with offspring fitness. Maternally transmitted bacteria were detected in both larval and adult offspring, and the relative abundances of specific taxa differed between life stages. Microbiota composition in adult offspring closely resembled that of mothers, despite dramatic shifts in the relative abundance of specific community members during the larval stage. Variability in microbiota composition among offspring was also greater than variability across the population of egg-laying mothers. Eggs that underwent a period of desiccation before hatching produced larval communities dominated by endospore-forming bacteria that were rare in maternal samples.</p> Conclusions <p>Overall, our results demonstrate vertical transmission of mosquito-associated microbiota across generations, including bacterial taxa that could potentially be leveraged for mosquito and mosquito-borne disease control</p> <p><MediaObject ID="MOESM36"><VideoObject FileRef="MediaObjects/40168_2026_2477_MOESM36_ESM.mp4" VideoID="Bsb9gKyFADKRVwA2N-Vjgb"><Caption Language="En" xml:lang="en"><CaptionContent><p>Video Abstract</p></CaptionContent></Caption></VideoObject></MediaObject></p>

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Vertical transmission of mosquito microbiota and its effects on offspring development

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月30日

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  • Holly L. Nichols,
  • Laura E. Brettell,
  • Miguel A. Saldaña,
  • Shivanand Hegde,
  • Eva Heinz,
  • Kathy Vaccaro,
  • Grant L. Hughes,
  • Kerri L. Coon

摘要

Background

The mosquito’s gut microbiota plays a crucial role in determining its capacity to transmit harmful viruses and parasites. Accordingly, manipulating mosquito gut microbiota is a promising avenue for reducing the transmission of mosquito-borne human pathogens. A successful microbial control campaign will require a thorough understanding of how bacteria are transmitted within mosquito populations. In two parallel but complementary studies using the yellow fever mosquito Aedes aegypti as a focal host species, we surveyed the vertical transmission of bacteria from individual mothers to cohorts of offspring maintained in a closed system.

Results

Laboratory- and field-derived mothers deposited bacteria that support offspring development, and the relative abundances of commonly transmitted taxa correlated with offspring fitness. Maternally transmitted bacteria were detected in both larval and adult offspring, and the relative abundances of specific taxa differed between life stages. Microbiota composition in adult offspring closely resembled that of mothers, despite dramatic shifts in the relative abundance of specific community members during the larval stage. Variability in microbiota composition among offspring was also greater than variability across the population of egg-laying mothers. Eggs that underwent a period of desiccation before hatching produced larval communities dominated by endospore-forming bacteria that were rare in maternal samples.

Conclusions

Overall, our results demonstrate vertical transmission of mosquito-associated microbiota across generations, including bacterial taxa that could potentially be leveraged for mosquito and mosquito-borne disease control

Video Abstract