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<p>Human microbiome research is expanding globally, yet remains dominated by samples, institutions, and leadership from the Global North. This imbalance undermines scientific validity, as microbiomes are shaped by socio-ecological context and temporal dynamics, and risks producing diagnostics and therapeutics that are not applicable across diverse populations. In this comment, we engage with van Daele et al.’s framework of co-laboration and argue for ethical, interdisciplinary, and locally led research models that center community participation, context-rich metadata, and equitable authorship. We outline structural requirements—governance tools, funding mechanisms, and accountability systems—needed to ensure these frameworks are implemented and advance both scientific integrity and global health equity.</p><p><MediaObject ID="MOESM1"> <VideoObject FileRef="MediaObjects/40168_2026_2371_MOESM1_ESM.mp4" VideoID="DNLktZwj2iyw-YBwkugBHr"> <Caption Language="En" xml:lang="en"> <CaptionContent> <p>Video Abstract</p> </CaptionContent> </Caption> </VideoObject> </MediaObject></p>

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Ethical design as a prerequisite for translational microbiome science

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月7日

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  • Jo-Ann S Passmore,
  • Abigail Nieves Delgado,
  • Anna-Ursula Happel

摘要

Human microbiome research is expanding globally, yet remains dominated by samples, institutions, and leadership from the Global North. This imbalance undermines scientific validity, as microbiomes are shaped by socio-ecological context and temporal dynamics, and risks producing diagnostics and therapeutics that are not applicable across diverse populations. In this comment, we engage with van Daele et al.’s framework of co-laboration and argue for ethical, interdisciplinary, and locally led research models that center community participation, context-rich metadata, and equitable authorship. We outline structural requirements—governance tools, funding mechanisms, and accountability systems—needed to ensure these frameworks are implemented and advance both scientific integrity and global health equity.

Video Abstract