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Background <p>Carbapenem-resistant hypervirulent <i>K. pneumoniae</i> (CR-HvKP) is a growing public health threat due to its virulence and limited treatment options. While prevalent in hospitals, its presence in livestock, particularly pigs, is poorly understood. The gut microbiome provides colonization resistance, but how it restricts CR-HvKP remains unclear.</p> Results <p>To further elucidate the colonization resistance mechanisms of the gut microbiota against CR-HvKP, we analyzed stool samples from piglets (L), nursery (N), fattening (F), and sows (PS) using microbiome modeling (Micolo) and competition assays. ST290 <i>K. pneumoniae</i> isolated from PS inhibited CR-HvKP via carbohydrate competition, with a pronounced effect observed for sucrose. Niche-specific supplementation with methyl pyruvate was found to partially alleviate this ecological inhibitory effect.</p> Conclusions <p>Carbohydrate-based interventions could be explored as potential therapeutic or prophylactic strategies to combat CR-HvKP colonization, thereby potentially improving animal and public health outcomes.</p> <p><MediaObject ID="MOESM2"> <VideoObject FileRef="MediaObjects/40168_2025_2245_MOESM2_ESM.mp4" VideoID="DZSBffRiYmb3j3FRG2Vh2A"> <Caption Language="En" xml:lang="en"> <CaptionContent> <p>Video Abstract</p> </CaptionContent> </Caption> </VideoObject> </MediaObject></p> Graphical Abstract <p></p>

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Carbohydrate competition by Enterobacteriaceae enhances colonization resistance to carbapenem-resistant hypervirulent K. pneumoniae

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月13日

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  • Gong Li,
  • Ling Jia,
  • Jie Li,
  • Ang Gao,
  • Xin Chen,
  • Jia-Hui Li,
  • Li-Juan Xia,
  • Shi-Ying Zhou,
  • Yi-Hao Lin,
  • Jin-Tao Yang,
  • Lei Wan,
  • Yu-Zhang He,
  • Ruan-Yang Sun,
  • Hao Ren,
  • Xin-Lei Lian,
  • Dong-Hao Zhao,
  • Xiao-Ping Liao,
  • Ya-Hong Liu,
  • Liang Chen,
  • Jian Sun

摘要

Background

Carbapenem-resistant hypervirulent K. pneumoniae (CR-HvKP) is a growing public health threat due to its virulence and limited treatment options. While prevalent in hospitals, its presence in livestock, particularly pigs, is poorly understood. The gut microbiome provides colonization resistance, but how it restricts CR-HvKP remains unclear.

Results

To further elucidate the colonization resistance mechanisms of the gut microbiota against CR-HvKP, we analyzed stool samples from piglets (L), nursery (N), fattening (F), and sows (PS) using microbiome modeling (Micolo) and competition assays. ST290 K. pneumoniae isolated from PS inhibited CR-HvKP via carbohydrate competition, with a pronounced effect observed for sucrose. Niche-specific supplementation with methyl pyruvate was found to partially alleviate this ecological inhibitory effect.

Conclusions

Carbohydrate-based interventions could be explored as potential therapeutic or prophylactic strategies to combat CR-HvKP colonization, thereby potentially improving animal and public health outcomes.

Video Abstract

Graphical Abstract