Scholarlink

Background <p>Colorectal cancer (CRC) development is influenced by both iron and gut microbiota composition. While iron supplementation is routinely used to manage anemia in CRC patients, it may also impact gut microbiota and promote tumorigenesis. In this study, we investigated the impact of initial gut microbiota composition on iron-promoted tumorigenesis. We performed fecal microbiota transplantation (FMT) in <i>Apc</i><sup><i>Min/</i>+</sup> mice using samples from healthy controls, CRC patients, and mice, followed by exposure to iron sufficient or iron excess diets.</p> Results <p>We found that iron supplementation promoted CRC and resulted in distinct gut microbiota changes in <i>Apc</i><sup><i>Min/</i>+</sup> mice receiving FMT from CRC patients (FMT-CRC), but not from healthy controls or mice. Oral treatment with identified bacterial strains, namely <i>Faecalibaculum rodentium</i>, <i>Holdemanella biformis</i>, <i>Bifidobacterium pseudolongum</i>, and <i>Alistipes inops,</i> protected FMT-CRC mice against iron-promoted tumorigenesis.</p> Conclusions <p>Our findings suggest that microbiota-targeted interventions may mitigate tumorigenic effects of iron supplementation in anemic patients with CRC.</p> Graphical Abstract <p></p> <p><MediaObject ID="MOESM2"> <VideoObject FileRef="MediaObjects/40168_2025_2101_MOESM2_ESM.mp4" VideoID="DffCdaLFWGz5j8kKHKKydB"> <Caption Language="En" xml:lang="en"> <CaptionContent> <p>Video Abstract</p> </CaptionContent> </Caption> </VideoObject> </MediaObject></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Initial gut microbiota composition is a determining factor in the promotion of colorectal cancer by oral iron supplementation: evidence from a murine model

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月21日

查看全文
  • Thibault Cuisiniere,
  • Roy Hajjar,
  • Manon Oliero,
  • Annie Calvé,
  • Gabriela Fragoso,
  • Hervé Vennin Rendos,
  • Claire Gerkins,
  • Nassima Taleb,
  • Marianne Gagnon-Konamna,
  • François Dagbert,
  • Rasmy Loungnarath,
  • Herawaty Sebajang,
  • Frank Schwenter,
  • Ramses Wassef,
  • Richard Ratelle,
  • Éric De Broux,
  • Carole Richard,
  • Manuela M. Santos

摘要

Background

Colorectal cancer (CRC) development is influenced by both iron and gut microbiota composition. While iron supplementation is routinely used to manage anemia in CRC patients, it may also impact gut microbiota and promote tumorigenesis. In this study, we investigated the impact of initial gut microbiota composition on iron-promoted tumorigenesis. We performed fecal microbiota transplantation (FMT) in ApcMin/+ mice using samples from healthy controls, CRC patients, and mice, followed by exposure to iron sufficient or iron excess diets.

Results

We found that iron supplementation promoted CRC and resulted in distinct gut microbiota changes in ApcMin/+ mice receiving FMT from CRC patients (FMT-CRC), but not from healthy controls or mice. Oral treatment with identified bacterial strains, namely Faecalibaculum rodentium, Holdemanella biformis, Bifidobacterium pseudolongum, and Alistipes inops, protected FMT-CRC mice against iron-promoted tumorigenesis.

Conclusions

Our findings suggest that microbiota-targeted interventions may mitigate tumorigenic effects of iron supplementation in anemic patients with CRC.

Graphical Abstract

Video Abstract