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<p>Superficial spreading melanoma (SSM) and nodular melanoma (NM) are the two histotypes that account for most cutaneous primary melanomas. We evaluated the mutational status for the genes underlying melanomagenesis among a series of SSMs and NMs from different Italian geographical areas. An increased number of mutated melanoma-driver genes was found to occur in both histological subtypes, with no specific mutational pattern distinctive for SSM and NM lesions, being significantly associated to shorter progression-free survival and poorer overall survival.</p>

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Mutation rates in main tumour driver genes predict prognosis in patients with superficial spreading or nodular primary melanoma: results from the CARAMEL study by the Italian Melanoma Intergroup (IMI)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月6日

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  • Maria Cristina Sini,
  • Jerry Polesel,
  • Sara Simi,
  • Antonella Manca,
  • Antonio Cossu,
  • Giovanni Battista Maestrale,
  • Daniela Massi,
  • Giuseppe Palmieri,
  • Maria Antonietta Pizzichetta,
  • Caterina Pinzani,
  • Vincenzo Canzonieri,
  • Stefano Astorino,
  • Paola Pasquini,
  • Maria Teresa Corradin,
  • Sandro Sulfaro,
  • Maurizio Lombardo,
  • Michele Paolo Cerati,
  • Giovanna Moretti,
  • Marisa Falduto

摘要

Superficial spreading melanoma (SSM) and nodular melanoma (NM) are the two histotypes that account for most cutaneous primary melanomas. We evaluated the mutational status for the genes underlying melanomagenesis among a series of SSMs and NMs from different Italian geographical areas. An increased number of mutated melanoma-driver genes was found to occur in both histological subtypes, with no specific mutational pattern distinctive for SSM and NM lesions, being significantly associated to shorter progression-free survival and poorer overall survival.