Scholarlink

Background <p>Emerging evidence highlights strong correlations between the cecal microbiome and abdominal fat deposition (AFD) in chickens. However, the specific microbial species driving this process remain unclear. This study aims to identify the key microbe and elucidate its underlying mechanism in regulating chicken AFD.</p> Results <p>First, cecal microbiota transplantation confirmed a causal relationship between the cecal microbiota and AFD. Subsequently, metagenomic and metatranscriptomic integrations identified <i>Alistipes communis</i> as a key microbe implicated in AFD. Finally, in vivo gavage integrated with multi-omics revealed that <i>A. communis</i> enhances AFD by disrupting host tryptophan and histidine metabolism. This was evidenced by the elevated concentrations of amino acid metabolism-related metabolites, including L-phosphoarginine and spermine in the cecum.</p> Conclusions <p>This study provides direct evidence that the cecal microbiome serves as a key driver in chicken AFD and identifies <i>A. communis</i> as a critical AFD regulator, offering valuable insights into the gut microbiome’s role in host obesity.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Microbiota transplantation and multi-omics profiling integration unveil the mechanism of Alistipes communis-driven abdominal fat deposition in chickens

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月20日

查看全文
  • Yang Jing,
  • Shuai Liu,
  • Li Leng,
  • Jiarui He,
  • Tianqi Wang,
  • Yunnan Guan,
  • Zhiyong Su,
  • Wenpeng Zhang,
  • Yumao Li,
  • Peng Luan,
  • Bohan Cheng,
  • Ning Wang,
  • Hui Li

摘要

Background

Emerging evidence highlights strong correlations between the cecal microbiome and abdominal fat deposition (AFD) in chickens. However, the specific microbial species driving this process remain unclear. This study aims to identify the key microbe and elucidate its underlying mechanism in regulating chicken AFD.

Results

First, cecal microbiota transplantation confirmed a causal relationship between the cecal microbiota and AFD. Subsequently, metagenomic and metatranscriptomic integrations identified Alistipes communis as a key microbe implicated in AFD. Finally, in vivo gavage integrated with multi-omics revealed that A. communis enhances AFD by disrupting host tryptophan and histidine metabolism. This was evidenced by the elevated concentrations of amino acid metabolism-related metabolites, including L-phosphoarginine and spermine in the cecum.

Conclusions

This study provides direct evidence that the cecal microbiome serves as a key driver in chicken AFD and identifies A. communis as a critical AFD regulator, offering valuable insights into the gut microbiome’s role in host obesity.