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<p>Alzheimer's disease (AD) is a major neurodegenerative disorder that causes severe cognitive decline and poses a significant burden on global health systems. Despite extensive research, effective treatments to stop neurodegeneration or promote neuronal regeneration in AD remain elusive. Psychoactive substances as modulators of neurophysiological functions, have received increased attention in research. The main psychoactive agents, such as central nervous system depressants and stimulants, cannabinoids, psychedelics, opioids and ketamine, are being explored for their abilities to enhance learning and cognitive performance and potential neurorestorative functions. In this paper, we review the molecular mechanisms and therapeutic potential of psychoactive substances in AD, in the aim to guide future research directions.</p>

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Psychoactive substances: novel molecular insights and therapeutic potential for Alzheimer's disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月25日

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  • Chonglei Fu,
  • Xuehui Li,
  • Xiaoxing Liu,
  • Yongbo Zheng,
  • Xiangxian Ma,
  • Bo Zhang,
  • Si Chen,
  • Lingming Hu,
  • Sizhen Su,
  • Xiaokun Wang,
  • Jie Sun,
  • Qingqing Yin,
  • Yumei Wang,
  • Xiaolong Fu,
  • Yanping Bao,
  • Yanxue Xue,
  • Tao Xin,
  • Lin Lu,
  • Guichang Zou

摘要

Alzheimer's disease (AD) is a major neurodegenerative disorder that causes severe cognitive decline and poses a significant burden on global health systems. Despite extensive research, effective treatments to stop neurodegeneration or promote neuronal regeneration in AD remain elusive. Psychoactive substances as modulators of neurophysiological functions, have received increased attention in research. The main psychoactive agents, such as central nervous system depressants and stimulants, cannabinoids, psychedelics, opioids and ketamine, are being explored for their abilities to enhance learning and cognitive performance and potential neurorestorative functions. In this paper, we review the molecular mechanisms and therapeutic potential of psychoactive substances in AD, in the aim to guide future research directions.