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Background <p>Coronary artery bypass grafting (CABG) and valve surgery provide substantial survival benefits for patients with advanced cardiac disease; however, postoperative health-related quality of life (HRQoL) remains variably affected and is influenced by multiple clinical and procedural factors. This study aimed to evaluate postoperative HRQoL levels during follow-up and identify factors associated with postoperative HRQoL following CABG and valve surgery.</p> Methods <p>In this prospective, multicenter cohort study, postoperative HRQoL was assessed using the validated Short Form-12 (SF-12), generating Physical Component Summary (PCS) and Mental Component Summary (MCS) scores. We did not collect preoperative SF-12 data; therefore, baseline HRQoL was not available for analysis. Demographic characteristics, comorbidities, functional status, and operative variables were collected. Multivariable regression models with center-stratified clustered robust standard errors were used to identify independent factors associated with physical and mental HRQoL.</p> Results <p>Male sex was independently associated with higher PCS scores (<i>β</i> = 1.88), whereas higher body mass index (<i>β</i> =  − 0.16), diabetes mellitus (<i>β</i> =  − 2.05), renal impairment (<i>β</i> =  − 4.36), advanced preoperative NYHA class (NYHA III: <i>β</i> =  − 3.79; NYHA IV: <i>β</i> =  − 5.96), and longer cardiopulmonary bypass (CPB) duration (<i>β</i> =  − 2.11 per 30-min increase) were independently associated with lower PCS scores. For MCS, only CPB duration was independently associated with lower scores (<i>β</i> =  − 1.45).</p> Conclusions <p>Postoperative HRQoL levels after CABG and valve surgery were associated with preoperative clinical and functional status, comorbidity burden, and operative complexity. These findings provide prospective multicenter data on postoperative HRQoL in cardiac surgery and may help inform future research on patient-reported recovery.</p> <p><i>Trial registration</i> Not applicable. This was an observational cohort study and did not involve assignment of participants to an intervention or clinical trial protocol.</p> Graphical Abstract <p></p>

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Determinants of health-related quality of life after cardiac surgery: a prospective multicenter cohort study in Palestine

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月2日

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  • Haitham Abu Khadija,
  • Abdalaziz Darwish,
  • Alaa Dabash,
  • Kareem Ibraheem,
  • Duha Najajra,
  • Yahya Z. Fraitekh,
  • Mohammad Masu’d,
  • Anwar Zahran,
  • Ibraheem AbuAlrub,
  • Tala Abu Awad,
  • Rahaf Mousa,
  • Sondos Dabash,
  • Ameen Abu Awad,
  • Alaa Khamaysa,
  • Ziad Salah,
  • Mohammed AbuBaha,
  • Raya Fuqha,
  • Sultan Hamarsheh,
  • Saja K. Karam,
  • Hamza A. Abdul-Hafez,
  • Yazan Hamdan,
  • Amjad Bdair,
  • Ayman Khaled,
  • Abdelrahman AbuArayes,
  • Masa Najjar,
  • Oday Salah Shaar,
  • Maria Agbaria,
  • Ayah Asaireh,
  • Waheed Qaisi,
  • Abdallateef Salih,
  • Taher Loai Barham,
  • Izzeddin Swidan,
  • Haya Adel Jaradat,
  • Maria Khaled Raed,
  • Hasan Khalili,
  • Rajaa Abed El Baqi,
  • Taleen Odeh,
  • Abeer Sallam,
  • Diana Basit,
  • Mohammad Mukbel,
  • Saeed Bakeer,
  • Zein Faydi,
  • Doaa Assi,
  • Yazan Motaz,
  • Sara Ibreites,
  • Mohammed Yaser Sholi,
  • Turkey Mokhaimar,
  • Monther M. Hroub,
  • Ahmad Alhashlamon,
  • Hamza M. A. Ghaith,
  • Iman M. Alwahsh,
  • Saja E. Abusabha,
  • Noor Khderat,
  • Yazeed Odeh,
  • Israa Awni Shawamreh,
  • Miar Saed Shuurab,
  • Elyaa Abuhijleh,
  • Maha Fayez Swaitti,
  • Abrar Nidal Neiroukh,
  • Reem J. Saad,
  • Nora I. Baraghithi,
  • Maryam Mansour,
  • Salem K. Qupp,
  • Ahmad Awies,
  • Sulaf Muath Daraghmeh,
  • Omar Heih,
  • Hiba Yaghmour,
  • Rahaf Almuhtaseb,
  • Nidal Nazzal,
  • Rahaf Kmail,
  • Mustafa Shehadeh,
  • Sameh F. Bsharat,
  • Wafiq Saleh Othman,
  • Ahmad K. Darwazah,
  • Moath Nairat,
  • Hasan Alkhatib,
  • Ghassan Balousha,
  • Nizar Abu Hamdeh,
  • Mohammad Alnees

摘要

Background

Coronary artery bypass grafting (CABG) and valve surgery provide substantial survival benefits for patients with advanced cardiac disease; however, postoperative health-related quality of life (HRQoL) remains variably affected and is influenced by multiple clinical and procedural factors. This study aimed to evaluate postoperative HRQoL levels during follow-up and identify factors associated with postoperative HRQoL following CABG and valve surgery.

Methods

In this prospective, multicenter cohort study, postoperative HRQoL was assessed using the validated Short Form-12 (SF-12), generating Physical Component Summary (PCS) and Mental Component Summary (MCS) scores. We did not collect preoperative SF-12 data; therefore, baseline HRQoL was not available for analysis. Demographic characteristics, comorbidities, functional status, and operative variables were collected. Multivariable regression models with center-stratified clustered robust standard errors were used to identify independent factors associated with physical and mental HRQoL.

Results

Male sex was independently associated with higher PCS scores (β = 1.88), whereas higher body mass index (β =  − 0.16), diabetes mellitus (β =  − 2.05), renal impairment (β =  − 4.36), advanced preoperative NYHA class (NYHA III: β =  − 3.79; NYHA IV: β =  − 5.96), and longer cardiopulmonary bypass (CPB) duration (β =  − 2.11 per 30-min increase) were independently associated with lower PCS scores. For MCS, only CPB duration was independently associated with lower scores (β =  − 1.45).

Conclusions

Postoperative HRQoL levels after CABG and valve surgery were associated with preoperative clinical and functional status, comorbidity burden, and operative complexity. These findings provide prospective multicenter data on postoperative HRQoL in cardiac surgery and may help inform future research on patient-reported recovery.

Trial registration Not applicable. This was an observational cohort study and did not involve assignment of participants to an intervention or clinical trial protocol.

Graphical Abstract