Scholarlink

Background and objective <p>Abnormal lipid metabolism plays a critical role in the development of cardiovascular diseases. However, limited evidence is available for the association between lipid and zinc levels in hypertensive population. This study aims to investigate the relationship between plasma zinc concentration and serum lipid levels among a group of rural Chinese hypertensive adults.</p> Methods <p>This study is a pre-specified sub-study of China Stroke Primary Prevention Trial (CSPPT), conducted in multiple Chinese communities, from May 2008 to August 2013. Multivariable linear regression models, adjusted for demographics, lifestyle factors, cardiometabolic indices, and trial design variables, were used to examine associations between plasma zinc concentration and lipid biomarkers (LDL-C, HDL-C, TG, and TC). Stratified analyses and interaction tests were performed to evaluate potential effect modification. Non-linear relationships were explored using smoothing techniques.</p> Results <p>1121 participants with mean age 60.15 ± 7.64&#xa0;years and 59.68% female were entered into the final analysis. Cross-sectional results showed that plasma zinc concentration was positively associated with triglyceride (TG) (<i>β</i> = 0.60, 95% CI 0.41–0.80). Longitudinal evidence also showed a positive association between zinc concentration and exit TG (<i>β</i> = 0.29, 95% CI 0.03–0.54), which is in accordance with previously reported results. Similarly, in the cross-sectional study, zinc was also found to be negatively correlated with HDL. However, there was no significant association between zinc and the rest of lipid profiles. Moreover, BMI and TG exhibited an interaction in the subgroup analysis.</p> Conclusion <p>Among rural Chinese hypertensive adults, higher plasma zinc concentration is associated with significantly higher triglycerides levels. This finding, if further confirmed, has important implications for nutritional counselling on precision supplement.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The relationship between plasma zinc concentration and serum lipids among Chinese hypertensive population: cross-sectional and longitudinal retrospective analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月6日

查看全文
  • Zaihua Cheng,
  • YuanSicheng Liang,
  • Tiantian Shen,
  • Zihan Chen,
  • Congcong Ding,
  • Junpei Li,
  • Tianyu Cao,
  • Ziheng Tan,
  • Huabo Ying,
  • Chunjiao You,
  • Yun Song,
  • Zena Huang,
  • Binyan Wang,
  • Xiaoshu Cheng,
  • Lishun Liu,
  • Xiao Huang

摘要

Background and objective

Abnormal lipid metabolism plays a critical role in the development of cardiovascular diseases. However, limited evidence is available for the association between lipid and zinc levels in hypertensive population. This study aims to investigate the relationship between plasma zinc concentration and serum lipid levels among a group of rural Chinese hypertensive adults.

Methods

This study is a pre-specified sub-study of China Stroke Primary Prevention Trial (CSPPT), conducted in multiple Chinese communities, from May 2008 to August 2013. Multivariable linear regression models, adjusted for demographics, lifestyle factors, cardiometabolic indices, and trial design variables, were used to examine associations between plasma zinc concentration and lipid biomarkers (LDL-C, HDL-C, TG, and TC). Stratified analyses and interaction tests were performed to evaluate potential effect modification. Non-linear relationships were explored using smoothing techniques.

Results

1121 participants with mean age 60.15 ± 7.64 years and 59.68% female were entered into the final analysis. Cross-sectional results showed that plasma zinc concentration was positively associated with triglyceride (TG) (β = 0.60, 95% CI 0.41–0.80). Longitudinal evidence also showed a positive association between zinc concentration and exit TG (β = 0.29, 95% CI 0.03–0.54), which is in accordance with previously reported results. Similarly, in the cross-sectional study, zinc was also found to be negatively correlated with HDL. However, there was no significant association between zinc and the rest of lipid profiles. Moreover, BMI and TG exhibited an interaction in the subgroup analysis.

Conclusion

Among rural Chinese hypertensive adults, higher plasma zinc concentration is associated with significantly higher triglycerides levels. This finding, if further confirmed, has important implications for nutritional counselling on precision supplement.