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Background <p>To investigate the variabilities in pancreatic volume measurements using CT and MRI for the normal pancreas.</p> Methods <p>This study included 21 participants with normal pancreases. All underwent both contrast-enhanced CT and MRI within 30&#xa0;days (mean interval: 2.2 ± 5.1&#xa0;days). Pancreatic segmentations based on water-phase and out-of-phase Dixon MRI images (3&#xa0;mm) and portal venous phase CT images (1&#xa0;mm and 3&#xa0;mm) were performed. CT images (1&#xa0;mm) and out-of-phase MRI images (3&#xa0;mm) were segmented twice. Bland–Altman analyses, intraclass correlation coefficients (ICCs), and paired samples t-tests were used to compare pancreatic volumes from CT and MRI.</p> Results <p>The pancreatic volumes measured by MRI were 18.8% smaller than those from CT scans (MRI: 68.9 ± 22.6 cm<sup>3</sup>; CT: 84.8 ± 30.1 cm<sup>3</sup>; <i>P</i> &lt; 0.001). For repeat measurements, CT (1&#xa0;mm) and MRI (3&#xa0;mm out-of-phase) showed excellent agreement, with CT yielding a mean volume difference of 9.7 cm<sup>3</sup> and limits of agreement (LOAs) of −&#xa0;7.5 to 27.0 cm<sup>3</sup> (ICC: 0.919; Dice: 0.83), and MRI showing a mean volume difference of −&#xa0;5.5 cm<sup>3</sup> and LOAs of −&#xa0;19.3 to 8.4 cm<sup>3</sup> (ICC: 0.920; Dice: 0.80). No significant differences were found in pancreatic volumes measured by CT with 1-mm and 3-mm slice thickness (<i>P</i> = 0.07) or between water-phase and out-of-phase MRI (<i>P</i> = 0.60).</p> Conclusion <p>The pancreatic volume measured by MRI was smaller than that measured by CT; it is not recommended to mix the CT and MRI if the follow-up of pancreatic volume is necessary during the therapy in the same patient.</p>

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Inter-modality variability of three-dimensional pancreatic volume measurements: CT versus MRI

  • 期刊论文

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  • 发表日期：

    2026年3月13日

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  • Qian Zhan,
  • Ziqi Kang,
  • Lei Wang,
  • Qingyu Gao,
  • Yisha Gao,
  • Lijia Wang,
  • Haidi Lu,
  • Yufei Chen,
  • Chengwei Shao,
  • Jianping Lu,
  • Chao Ma

摘要

Background

To investigate the variabilities in pancreatic volume measurements using CT and MRI for the normal pancreas.

Methods

This study included 21 participants with normal pancreases. All underwent both contrast-enhanced CT and MRI within 30 days (mean interval: 2.2 ± 5.1 days). Pancreatic segmentations based on water-phase and out-of-phase Dixon MRI images (3 mm) and portal venous phase CT images (1 mm and 3 mm) were performed. CT images (1 mm) and out-of-phase MRI images (3 mm) were segmented twice. Bland–Altman analyses, intraclass correlation coefficients (ICCs), and paired samples t-tests were used to compare pancreatic volumes from CT and MRI.

Results

The pancreatic volumes measured by MRI were 18.8% smaller than those from CT scans (MRI: 68.9 ± 22.6 cm3; CT: 84.8 ± 30.1 cm3; P < 0.001). For repeat measurements, CT (1 mm) and MRI (3 mm out-of-phase) showed excellent agreement, with CT yielding a mean volume difference of 9.7 cm3 and limits of agreement (LOAs) of − 7.5 to 27.0 cm3 (ICC: 0.919; Dice: 0.83), and MRI showing a mean volume difference of − 5.5 cm3 and LOAs of − 19.3 to 8.4 cm3 (ICC: 0.920; Dice: 0.80). No significant differences were found in pancreatic volumes measured by CT with 1-mm and 3-mm slice thickness (P = 0.07) or between water-phase and out-of-phase MRI (P = 0.60).

Conclusion

The pancreatic volume measured by MRI was smaller than that measured by CT; it is not recommended to mix the CT and MRI if the follow-up of pancreatic volume is necessary during the therapy in the same patient.