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Objective <p>Although numerous studies have explored the association between the lactate-to-albumin ratio (LAR) and various diseases, focused research on chronic kidney disease (CKD) remains scarce. This study aimed to investigate the relationship between LAR and clinical outcomes in patients with&#xa0;CKD&#xa0;admitted in intensive care unit (ICU), utilizing data obtained from a regional database.</p> Methods <p>From January 2020 to July 2024, 570 CKD patients admitted in &#xa0;ICU in&#xa0;Changsha Central Hospital were enrolled in this retrospective cohort study. The LAR was calculated from the highest lactate and albumin levels within 24 h of admission. The primary outcome was 30-day all-cause mortality. Cox proportional hazards models were used to assess the association, and Kaplan–Meier analysis with log-rank test was performed. A multivariable model combining LAR with other predictors was also developed.</p> Results <p>Research findings indicate, revealing a median LAR of 0.44. The 30-day mortality rate was identified as 53.86% (n = 307). After adjusting for various confounding factors, a significant positive correlation between LAR and 30-day mortality was observed. For each unit increase in LAR, the risk of 30-day&#xa0;mortality escalated by 65% (OR = 1.65, 95% CI: 1.17–2.33, p = 0.004).</p> Conclusion <p>The LAR at admission was independently associated with increased 30-day mortality in patients with CKD&#xa0;admitted in ICU and may serve as a useful prognostic marker, especially when combined with other clinical variables.</p>

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Correlation between the lactate-to-albumen ratio and 30-day mortality in patients with chronic kidney disease admitted to intensive care

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月5日

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  • Kexiang Qin,
  • Jiao Qin,
  • Ning Ding

摘要

Objective

Although numerous studies have explored the association between the lactate-to-albumin ratio (LAR) and various diseases, focused research on chronic kidney disease (CKD) remains scarce. This study aimed to investigate the relationship between LAR and clinical outcomes in patients with CKD admitted in intensive care unit (ICU), utilizing data obtained from a regional database.

Methods

From January 2020 to July 2024, 570 CKD patients admitted in  ICU in Changsha Central Hospital were enrolled in this retrospective cohort study. The LAR was calculated from the highest lactate and albumin levels within 24 h of admission. The primary outcome was 30-day all-cause mortality. Cox proportional hazards models were used to assess the association, and Kaplan–Meier analysis with log-rank test was performed. A multivariable model combining LAR with other predictors was also developed.

Results

Research findings indicate, revealing a median LAR of 0.44. The 30-day mortality rate was identified as 53.86% (n = 307). After adjusting for various confounding factors, a significant positive correlation between LAR and 30-day mortality was observed. For each unit increase in LAR, the risk of 30-day mortality escalated by 65% (OR = 1.65, 95% CI: 1.17–2.33, p = 0.004).

Conclusion

The LAR at admission was independently associated with increased 30-day mortality in patients with CKD admitted in ICU and may serve as a useful prognostic marker, especially when combined with other clinical variables.