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Background <p>Chronic inflammation and insulin resistance underpin frailty; the C-reactive protein–triglyceride-glucose index (CTI) integrates these processes. We assessed the association between CTI and frailty in a nationally representative Chinese population.</p> Methods <p>We analyzed 9,555 adults aged ≥ 45&#xa0;years from the nationally representative 2015 China Health and Retirement Longitudinal Study (CHARLS). Frailty was assessed using a 32-deficit frailty index (FI), computed on a 0–1 scale and multiplied by 100 for presentation (scaled from 0 to100); frailty was defined as FI ≥ 25 (equivalently ≥ 0.25).Associations were estimated using survey-weighted linear regression (FI, continuous) and survey-weighted logistic regression (frailty). Nonlinearity was examined with restricted cubic splines; where supported, segmented regression was used to identify an inflection point.</p> Results <p>Each 1-unit higher CTI was associated with a 0.71-point higher FI (95% CI 0.37–1.05; <i>p</i> &lt; 0.001) and 15% higher odds of frailty (OR, 1.15; 95% CI 1.04–1.27; <i>p</i> = 0.006). Compared with the lowest tertile, the highest tertile had a higher FI (β, 0.91; 95% CI 0.30–1.51; <i>p</i> = 0.0035) and greater odds of frailty (OR, 1.22; 95% CI 1.02–1.45; <i>p</i> = 0.029). Spline analyses demonstrated an overall positive association; piecewise models identified a threshold near CTI ≈7.95 (null association below; positive above).</p> Conclusions <p>CTI is independently associated with frailty in a population-representative cohort. Therefore, CTI-based approaches may facilitate risk stratification in aging populations, while longitudinal validation is warranted to establish prognostic value.</p>

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Inflammation meets insulin resistance: the role of the CRP-triglyceride-glucose index in association with frailty among middle-aged and older adults in China

  • 期刊论文

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  • 发表日期：

    2026年2月2日

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  • Wei Yan,
  • Jing Zhao,
  • Qianyi Hao,
  • Shenghua Zhou,
  • Zhenmin Lang,
  • Guodong Gao,
  • Fan Yang,
  • Dingyu Wang

摘要

Background

Chronic inflammation and insulin resistance underpin frailty; the C-reactive protein–triglyceride-glucose index (CTI) integrates these processes. We assessed the association between CTI and frailty in a nationally representative Chinese population.

Methods

We analyzed 9,555 adults aged ≥ 45 years from the nationally representative 2015 China Health and Retirement Longitudinal Study (CHARLS). Frailty was assessed using a 32-deficit frailty index (FI), computed on a 0–1 scale and multiplied by 100 for presentation (scaled from 0 to100); frailty was defined as FI ≥ 25 (equivalently ≥ 0.25).Associations were estimated using survey-weighted linear regression (FI, continuous) and survey-weighted logistic regression (frailty). Nonlinearity was examined with restricted cubic splines; where supported, segmented regression was used to identify an inflection point.

Results

Each 1-unit higher CTI was associated with a 0.71-point higher FI (95% CI 0.37–1.05; p < 0.001) and 15% higher odds of frailty (OR, 1.15; 95% CI 1.04–1.27; p = 0.006). Compared with the lowest tertile, the highest tertile had a higher FI (β, 0.91; 95% CI 0.30–1.51; p = 0.0035) and greater odds of frailty (OR, 1.22; 95% CI 1.02–1.45; p = 0.029). Spline analyses demonstrated an overall positive association; piecewise models identified a threshold near CTI ≈7.95 (null association below; positive above).

Conclusions

CTI is independently associated with frailty in a population-representative cohort. Therefore, CTI-based approaches may facilitate risk stratification in aging populations, while longitudinal validation is warranted to establish prognostic value.