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<p>Stroke-associated infection (SAI) is a significant complication of stroke, with approximately 30% of stroke patients developing infections, primarily respiratory and urinary tract infections. These infections can severely impact prognosis and increase the economic burden. While dysphagia is a known independent risk factor for stroke-associated pneumonia, research shows that stroke patients without aspiration or related risk factors, such as dysphagia and impaired consciousness, also exhibit a high incidence of non-aspiration stroke-associated infections (NA-SAI). This comprehensive article meticulously examines and reviews the risk factors, pathophysiological underpinnings, and therapeutic strategies for NA-SAI, with the aim of enhancing clinicians' comprehension and management of this condition.</p>

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Frontiers and literature review on non-aspiration stroke-associated infections

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月21日

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  • Wen Zhao,
  • Xuanyue Yu,
  • Yuhua Zhang,
  • Shuya Cai,
  • Jianwen Lin,
  • Pan Qin,
  • Yi Sui,
  • Shiwei Du,
  • Dong Chen,
  • Yi Liu

摘要

Stroke-associated infection (SAI) is a significant complication of stroke, with approximately 30% of stroke patients developing infections, primarily respiratory and urinary tract infections. These infections can severely impact prognosis and increase the economic burden. While dysphagia is a known independent risk factor for stroke-associated pneumonia, research shows that stroke patients without aspiration or related risk factors, such as dysphagia and impaired consciousness, also exhibit a high incidence of non-aspiration stroke-associated infections (NA-SAI). This comprehensive article meticulously examines and reviews the risk factors, pathophysiological underpinnings, and therapeutic strategies for NA-SAI, with the aim of enhancing clinicians' comprehension and management of this condition.