Scholarlink

Background <p>Early-onset liver cancer is emerging as a critical global health challenge. This study aimed to evaluate the burden of early-onset liver cancer from various perspectives, as well as the contributions of associated risk factors.</p> Methods <p>We utilized data associated with early-onset liver cancer from the Global Burden of Disease study 2021 to assess the incidence and disability-adjusted life year (DALYs) burden. The estimated annual percentage change (EAPC) was also calculated to evaluate temporal trends.</p> Results <p>On a global scale, the disease burden of early-onset liver cancer decreased significantly, whereas only early-onset liver cancer due to nonalcoholic steatohepatitis (NASH) showed an increasing incidence burden. Males had a substantially higher early-onset liver cancer burden compared to females. Regionally, Australasia exhibited the most rapid growth in the age-standardized incidence rate of early-onset liver cancer (EAPC = 3.09). By countries, the highest age-standardized incidence rate was observed in Mongolia (12.93 per 100,000). According to sociodemographic index (SDI), early-onset liver cancer burden demonstrated a significant negative association with SDI. Among risk factors, alcohol use played a leading role in the DALYs, and high body-mass index showed the largest increase over the past 32&#xa0;years. Additionally, high-income North America accounted for the highest attributable proportions of high body-mass index in 2021.</p> Conclusion <p>Less developed countries bear a heavy burden of early-onset liver cancer, necessitating more effective interventions. Meanwhile, the escalating NASH-related early-onset liver cancer burden highlights the preventive potential of weight control, especially in high-income regions where a high body-mass index predominates.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Epidemiological trends and risk attribution of early-onset liver cancer: insights from the Global Burden of Disease study 2021

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月4日

查看全文
  • Xiaofei Fan,
  • Xin Huang,
  • Qianqian Wu,
  • Yajun Miao

摘要

Background

Early-onset liver cancer is emerging as a critical global health challenge. This study aimed to evaluate the burden of early-onset liver cancer from various perspectives, as well as the contributions of associated risk factors.

Methods

We utilized data associated with early-onset liver cancer from the Global Burden of Disease study 2021 to assess the incidence and disability-adjusted life year (DALYs) burden. The estimated annual percentage change (EAPC) was also calculated to evaluate temporal trends.

Results

On a global scale, the disease burden of early-onset liver cancer decreased significantly, whereas only early-onset liver cancer due to nonalcoholic steatohepatitis (NASH) showed an increasing incidence burden. Males had a substantially higher early-onset liver cancer burden compared to females. Regionally, Australasia exhibited the most rapid growth in the age-standardized incidence rate of early-onset liver cancer (EAPC = 3.09). By countries, the highest age-standardized incidence rate was observed in Mongolia (12.93 per 100,000). According to sociodemographic index (SDI), early-onset liver cancer burden demonstrated a significant negative association with SDI. Among risk factors, alcohol use played a leading role in the DALYs, and high body-mass index showed the largest increase over the past 32 years. Additionally, high-income North America accounted for the highest attributable proportions of high body-mass index in 2021.

Conclusion

Less developed countries bear a heavy burden of early-onset liver cancer, necessitating more effective interventions. Meanwhile, the escalating NASH-related early-onset liver cancer burden highlights the preventive potential of weight control, especially in high-income regions where a high body-mass index predominates.