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Background <p>Cervical cancer treatment faces challenges in identifying specific targets within heterogeneous tumors. Current antitumor immunotherapy for cervical cancer is constrained by the lack of corresponding therapeutic targets.</p> Methods <p>We developed glycoprotein E (gE)-pHLIP nanomicelles, an antigen-targeting peptide particle anchored on cell membranes. This system enables tumor-targeted antigen release, labels tumor tissues, and leverages pre-existing immune responses for tumor elimination by "disguising" cancer cells as viral invaders.</p> Results <p>In animal models, pre-immunization with g(E) combined with g(E)-pHLIP treatment demonstrated suppressed tumor growth. Reduced tumor recurrence was observed post-treatment. The system successfully activated the body’s antiviral immune response against labeled tumor cells.</p> Conclusions <p>This study developed a novel protein–peptide system that labels cervical cancer cells, “disguises” them as viral invaders to the body, and subsequently eliminates tumors through the body’s antiviral immune response.</p>

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g(E)-pHLIP promote virus Immunity to destroy Cervical Cancer Cell

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月14日

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  • Zhangguo Ying,
  • Mengmeng Shi,
  • Wangang Gong,
  • Yujie Chen,
  • Guangyi Jiang

摘要

Background

Cervical cancer treatment faces challenges in identifying specific targets within heterogeneous tumors. Current antitumor immunotherapy for cervical cancer is constrained by the lack of corresponding therapeutic targets.

Methods

We developed glycoprotein E (gE)-pHLIP nanomicelles, an antigen-targeting peptide particle anchored on cell membranes. This system enables tumor-targeted antigen release, labels tumor tissues, and leverages pre-existing immune responses for tumor elimination by "disguising" cancer cells as viral invaders.

Results

In animal models, pre-immunization with g(E) combined with g(E)-pHLIP treatment demonstrated suppressed tumor growth. Reduced tumor recurrence was observed post-treatment. The system successfully activated the body’s antiviral immune response against labeled tumor cells.

Conclusions

This study developed a novel protein–peptide system that labels cervical cancer cells, “disguises” them as viral invaders to the body, and subsequently eliminates tumors through the body’s antiviral immune response.