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Purpose <p>Keratorefractive lenticule extraction (KLEx) is widely used for myopia correction. This study aims to investigate the relationships among the designed lenticular area (DLA), lenticule stretched preparation (LSP), and the achieved functional optical zone (AFOZ) to identify factors influencing these discrepancies.</p> Setting <p>The study was conducted at the Eye &amp; ENT Hospital of Fudan University, Shanghai.</p> Design <p>The study was a non-randomized, prospective analysis of patients’ surgical parameters.</p> Methods <p>29 young adults who underwent KLEx for myopia correction were included. Preoperative data, including spherical equivalent and axial length, were recorded. The removed lenticule was stained, flattened, and measured using ImageJ software to calculate the LSP area. Postoperative AFOZ was assessed using Pentacam topography. Statistical analysis compared LSP, DLA, and AFOZ and correlated differences with clinical parameters.</p> Results <p>The mean age of the patients was 23.07 ± 4.76&#xa0;years, with a median spherical equivalent of −&#xa0;4.3755.375, (−&#xa0;5.375, −&#xa0;3.188) D. The AFOZ was smaller than the DLA (35.26 (35.260, 35.260)&#xa0;mm<sup>2</sup> vs. 36.32 (35.790, 36.320) mm<sup>2</sup>), likely due to corneal remodeling. Axial length significantly correlated with the LSP–DLA discrepancy (<i>P</i> = 0.005), with longer axial lengths associated with smaller differences, suggesting that increased axial length reduces corneal elasticity. Spherical equivalent also correlated significantly with the AFOZ–DLA discrepancy (<i>P</i> = 0.047).</p> Conclusions <p>Anatomical factors such as axial length and myopia severity affect the AFOZ in KLEx. Future research should incorporate additional biomechanical and imaging parameters to enhance the accuracy of outcome predictions.</p>

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Influence of axial length and myopia severity on the achieved optical zone in KLEx surgery: a pilot study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月11日

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  • Jing Wang,
  • Liren Zheng,
  • Shu Zhang,
  • Xiaohong Zheng,
  • Yinan Han,
  • Ke Zheng

摘要

Purpose

Keratorefractive lenticule extraction (KLEx) is widely used for myopia correction. This study aims to investigate the relationships among the designed lenticular area (DLA), lenticule stretched preparation (LSP), and the achieved functional optical zone (AFOZ) to identify factors influencing these discrepancies.

Setting

The study was conducted at the Eye & ENT Hospital of Fudan University, Shanghai.

Design

The study was a non-randomized, prospective analysis of patients’ surgical parameters.

Methods

29 young adults who underwent KLEx for myopia correction were included. Preoperative data, including spherical equivalent and axial length, were recorded. The removed lenticule was stained, flattened, and measured using ImageJ software to calculate the LSP area. Postoperative AFOZ was assessed using Pentacam topography. Statistical analysis compared LSP, DLA, and AFOZ and correlated differences with clinical parameters.

Results

The mean age of the patients was 23.07 ± 4.76 years, with a median spherical equivalent of − 4.3755.375, (− 5.375, − 3.188) D. The AFOZ was smaller than the DLA (35.26 (35.260, 35.260) mm2 vs. 36.32 (35.790, 36.320) mm2), likely due to corneal remodeling. Axial length significantly correlated with the LSP–DLA discrepancy (P = 0.005), with longer axial lengths associated with smaller differences, suggesting that increased axial length reduces corneal elasticity. Spherical equivalent also correlated significantly with the AFOZ–DLA discrepancy (P = 0.047).

Conclusions

Anatomical factors such as axial length and myopia severity affect the AFOZ in KLEx. Future research should incorporate additional biomechanical and imaging parameters to enhance the accuracy of outcome predictions.